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Table 3 Case only analysis of pathogenic variants in DCIS by age

From: Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years

Gene Pathogenic variants in cases aged < 40 (N = 100) Pathogenic variants in cases aged 40–49 (N = 555) OR (95% CI) P value
BRCA2 9 (9%) 13 (2.3%) 4.12 (1.75–9.69) 0.003
CHEK2 3 (3%) 13 (2.3%) 1.29 (0.37–4.54) 0.72
PALB2 1 (1%) 5 (0.9%) 1.11 (0.13–9.53) 1
BRCA1 1 (1%) 3 (0.5%) 1.86 (0.19–17.90) 0.485
TP53 1 (1%) 2 (0.4%) 2.79 (0.25–30.86) 0.39