Table 3 Case only analysis of pathogenic variants in DCIS by age
Gene | Pathogenic variants in cases aged < 40 (N = 100) | Pathogenic variants in cases aged 40–49 (N = 555) | OR (95% CI) | P value |
|---|---|---|---|---|
BRCA2 | 9 (9%) | 13 (2.3%) | 4.12 (1.75–9.69) | 0.003 |
CHEK2 | 3 (3%) | 13 (2.3%) | 1.29 (0.37–4.54) | 0.72 |
PALB2 | 1 (1%) | 5 (0.9%) | 1.11 (0.13–9.53) | 1 |
BRCA1 | 1 (1%) | 3 (0.5%) | 1.86 (0.19–17.90) | 0.485 |
TP53 | 1 (1%) | 2 (0.4%) | 2.79 (0.25–30.86) | 0.39 |