Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer

Breast Cancer Research

Table 2 Interferon-stimulated genes implicated in IBC and their specific functions

Function	Function in IBC	ISG	Reference
DNA damage resistance	Inferred	STAT1, IFI27, MX1/2, PLSCR1, OAS1/2/3, IRF9, IFITM1	[14, 38]
Migration/invasion	Confirmed	IFITM1, STAT2	[14]
Positive feedback	Inferred	IRF3, IRF7, IRF9	[22]
Negative regulation	Inferred	SOCS1, USP18	[17, 22]

A selected list of ISGs stimulated by IFNα is listed with corresponding function derived from the literature. The confirmation of the function of ISGs in IBC is outlined. All ISGs have confirmed expression in IBC in our unpublished data

ISSN: 1465-542X