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Table 1 Transcription factor complexes and their control of interferon-stimulated genes

From: Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer

ISGF3 U-ISGF3 GAS
MX1/2 IRF9 MX1/2 IFITM1
IFITM1 IRF4 IFITM1 STAT4
PLSCR1 cGAS PLSCR1 IRF1
OAS1/2/3 STAT1 OAS1/2/3 IRF8
SOCS STAT2 IRF7 IDO
USP18 NOS2 STAT1 NOS2
ISG15   IFI27 PDGFRA
IRF3   IFI44 KRT14
IRF7    IRF2
  1. ISGF3 (interferon-stimulated gene factor 3), consists of phosphorylated STAT1 and STAT2 dimers bound to IRF9; U-ISGF3 (unphosphorylated interferon-stimulated gene factor 3), consists of a dimer of unphosphorylated STAT proteins bound to IRF9; GAS (gamma activated sequence), consists of phosphorylated STAT1 dimers