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Table 1 Transcription factor complexes and their control of interferon-stimulated genes

From: Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer

ISGF3

U-ISGF3

GAS

MX1/2

IRF9

MX1/2

IFITM1

IFITM1

IRF4

IFITM1

STAT4

PLSCR1

cGAS

PLSCR1

IRF1

OAS1/2/3

STAT1

OAS1/2/3

IRF8

SOCS

STAT2

IRF7

IDO

USP18

NOS2

STAT1

NOS2

ISG15

 

IFI27

PDGFRA

IRF3

 

IFI44

KRT14

IRF7

  

IRF2

  1. ISGF3 (interferon-stimulated gene factor 3), consists of phosphorylated STAT1 and STAT2 dimers bound to IRF9; U-ISGF3 (unphosphorylated interferon-stimulated gene factor 3), consists of a dimer of unphosphorylated STAT proteins bound to IRF9; GAS (gamma activated sequence), consists of phosphorylated STAT1 dimers