Table 3 Association of polygenic risk score (PRS) with breast cancer risk and evaluation of confounding due to family history and density measures (adjusted PD and adjusted DA). All eight studies combined and subset to cohort/population-based studies. All models adjusted for age, 1/BMI, and study
Model | N case/N control | PRS OR (95% CI) | +Family history OR (95% CI) | +adjusted PD OR (95% CI) | +adjusted DA OR (95% CI) |
|---|---|---|---|---|---|
Overall sample | |||||
 Overall PRS (per 1 SD) | 3628/5126 | 1.52 (1.45, 1.59) | 1.52 (1.44, 1.59) | 1.50 (1.42, 1.57) | 1.50 (1.43, 1.58) |
PRS quintile | |||||
 1 | 349/1033 | 0.51 (0.44, 0.60) | 0.51 (0.44, 0.61) | 0.53 (0.45, 0.63) | 0.53 (0.45, 0.63) |
 2 | 535/1008 | 0.80 (0.69, 0.93) | 0.78 (0.67, 0.92) | 0.80 (0.69, 0.94) | 0.80 (0.69, 0.94) |
 3 (Ref) | 687/1024 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 4 | 887/1032 | 1.31 (1.14, 1.50) | 1.31 (1.14, 1.51) | 1.32 (1.14, 1.53) | 1.33 (1.15, 1.53) |
 5 | 1170/1029 | 1.66 (1.45, 1.90) | 1.65 (1.44, 1.90) | 1.64 (1.43, 1.89) | 1.65 (1.44, 1.91) |
Cohort/population-based studies only | |||||
 Overall PRS (per 1 SD) | 2439/3895 | 1.56 (1.48, 1.66) | 1.55 (1.47, 1.65) | 1.54 (1.45, 1.63) | 1.55 (1.46, 1.64) |
PRS quintile | |||||
 1 | 232/786 | 0.51 (0.42, 0.62) | 0.51 (0.42, 0.62) | 0.53 (0.43, 0.65) | 0.53 (0.43, 0.64) |
 2 | 361/776 | 0.80 (0.66, 0.95) | 0.79 (0.66, 0.94) | 0.80 (0.67, 0.96) | 0.80 (0.67, 0.96) |
 3 (Ref) | 464/789 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 4 | 589/793 | 1.30 (1.10, 1.53) | 1.28 (1.08, 1.52) | 1.29 (1.09, 1.54) | 1.30 (1.10, 1.54) |
 5 | 793/751 | 1.79 (1.52, 2.11) | 1.76 (1.50, 2.08) | 1.76 (1.49, 2.08) | 1.77 (1.50, 2.09) |