Fig. 5

Therapeutic IFN-β represses OSM-mediated tumor growth. a Treatment strategy for intra-tumoral administration of recombinant human IFN-β into established BT549-OSM tumors (at 7 days post-engraftment) from top to bottom: group 1 (control no treatment), group 2 (single high dose IFN-β 50,000 IU on day 7), group 3 (25,000 IU administered on day 7 and day 14), and group 4 (25,000 IU administered on days 7, 10, 14, 17). b IFN-β treatment significantly reduced OSM-mediated tumor growth under all treatment conditions as demonstrated by repressed tumor weights on day 21 (end of experiment) (one-way ANOVA, ****P < 0.0001) ± SD, n = 5 mice