Fig. 4

Cumulative risk of breast cancer by regular aspirin use and underlying familial risk. Legend: Predicted age-specific cumulative risk (from birth) for breast cancer, by regular aspirin use and familial risk, where 12% lifetime risk is approximately the population risk of breast cancer by age 80 years, where moderate familial risk (> 20–30% full lifetime BOADICEA) is equivalent to having one affected first-degree relative, and high familial risk (> 30% full lifetime BOADICEA) is equivalent to having two affected first-degree relatives