Fig. 3

Adjusted hazard ratios and 95% confidence intervals of breast cancer risk comparing regular users of ibuprofen and other NSAIDs and acetaminophen with non-regular users by subgroup in the combined cohort of the Breast Cancer Prospective Family Study Cohort (N = 8233). Legend: Models are adjusted for race/ethnicity, study center, baseline age, familial risk profile, cigarette smoking, alcohol consumption, hormone therapy use, hormonal birth control use, and regular use of other medications; stratified by birth cohort. Sample sizes: non-carriers (includes true negatives and women who did not undergo genetic testing) N = 6395; BRCA1 mutation carriers N = 506; BRCA2 mutation carriers N = 418; ER status: N = 7319; attained age 45: N = 2222; attained age 55: N = 4401; attained age 65: N = 6325. Alternative ER subtypes were censored at diagnosis (e.g., ER negative and ER status missing breast cancers censored at age at diagnosis in the analysis of ER-positive breast cancer). P values are for the Wald chi-square test statistic for the interaction between categories of familial risk profile or BRCA carrier status and regular medication use