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Fig. 5 | Breast Cancer Research

Fig. 5

From: BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

Fig. 5

BRCA1 overexpression partially restores H3K27ac marks and transcription in BRCA1185delAG/+ MCF10A clones. a, b Relative H3K27ac levels at TNFAIP3 (a) and SOD2 (b) super-enhancers. The graph is an average of three independent experiments with control and BRCA1 ectopic overexpression clones. c, d Relative mRNA expression of TNFAIP3 (c) and SOD2 (d). The graph is an average of three independent experiments. *P < 0.05 by two-tailed t test. Error bars represent s.e.m

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