Fig. 2

MIR2052HG regulates breast cancer cell growth through LMTK3- mediated signaling. a–d Overexpression of LMTK3 in MIR2052HG knocked-down MCF7/AC1 (a, b) and CAMA-1 (c, d) cells reversed the phenotypes of cell proliferation (a, c) and colony formation (b, d). Knockdown efficiency was determined by qRT-PCR. Overexpression of LMTK3 was determined by western blotting (a, c; right panel). Representative pictures of colony formation from three independent experiments are shown (b, d; left panel). The colony formation is quantified (b, d; right panel). Error bars represent SEM; **p < 0.01