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Fig. 2 | Breast Cancer Research

Fig. 2

From: Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

Fig. 2

ERBB2 interaction screen. a Schematic of the BiFC assay used to visualise ERBB2 dimerization. b Confocal fluorescence microscopy of HEK-293 T cells following transfection with plasmids containing a full-length Venus control, ERBB2-V1, ERBB2-V2 or co-transfected with ERBB2-V1 and ERBB2-V2 (scale bar = 25 μm). c Dendrogram showing the sequence-based relationship between all 61 RTKs and their ERBB2 interaction status detected using the BiFC assay and high-content imaging. The dendrogram was adapted from Manning et al. 2002 (24). d Confocal fluorescence microscopy of HEK-293 T cells following transfection with plasmids containing ERBB2-V1 and the V2 tagged RTKs indicated (scale bar = 15 μm)

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