Table 2 Relative risks calculated using random-effects meta-analysis and attributable risk fractions
Risk factor | RR estimates | Attributable risk (%) for Gail+ AMH + testosterone modelb | |||
|---|---|---|---|---|---|
Gail | Gail + AMH | Gail + testosterone | Gail + AMH + testosterone | ||
Age at menarche, years | 0.67% | ||||
< 12 | 1.00 (0.90, 1.11) | 1.02 (0.91, 1.13) | 1.00 (0.90, 1.11) | 1.01 (0.91, 1.12) | |
12–13 | 1.00 (0.90, 1.11) | 1.01 (0.91, 1.12) | 1.00 (0.90, 1.11) | 1.01 (0.91, 1.12) | |
≥ 14 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
Age at first live birth, years | 18.47% | ||||
< 20 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
20–24 | 1.11 (1.00, 1.24) | 1.12 (1.00, 1.25) | 1.12 (1.00, 1.26) | 1.12 (1.00, 1.26) | |
25–29 or nulliparous | 1.24 (1.11, 1.38) | 1.25 (1.12, 1.39) | 1.26 (1.12, 1.41) | 1.26 (1.13, 1.42) | |
≥ 30 | 1.38 (1.23, 1.54) | 1.40 (1.25, 1.56) | 1.41 (1.26, 1.58) | 1.42 (1.27, 1.60) | |
Number of benign breast biopsies | 8.13% | ||||
0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
≥ 1 | 1.58 (1.33, 1.88) | 1.55 (1.31, 1.85) | 1.59 (1.34, 1.89) | 1.56 (1.31, 1.86) | |
Number of first-degree family members with breast cancera | 6.56% | ||||
0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
1 | 1.58 (1.32, 1.89) | 1.57 (1.31, 1.88) | 1.57 (1.30, 1.88) | 1.56 (1.30, 1.87) | |
> 1 | 2.49 (2.08, 2.99) | 2.47 (2.06, 2.96) | 2.45 (2.04, 2.94) | 2.43 (2.03, 2.92) | |
AMH | 19.38% | ||||
Q1 | – | 1.0 (ref) | – | 1.0 (ref) | |
Q2 | – | 1.16 (1.04, 1.29) | – | 1.15 (1.03, 1.28) | |
Q3 | – | 1.34 (1.20, 1.49) | – | 1.33 (1.19, 1.48) | |
Q4 | – | 1.55 (1.39, 1.73) | – | 1.53 (1.37, 1.70) | |
Testosterone | 9.48% | ||||
Q1 | – | – | 1.0 (ref) | 1.0 (ref) | |
Q2 | – | – | 1.08 (1.02, 1.15) | 1.07 (1.00, 1.14) | |
Q3 | – | – | 1.17 (1.10, 1.25) | 1.14 (1.07, 1.22) | |
Q4 | – | – | 1.27 (1.19, 1.35) | 1.22 (1.15, 1.30) | |