|
Risk factor
|
RR estimates
|
Attributable risk (%) for Gail+ AMH + testosterone modelb
|
|---|
|
Gail
|
Gail + AMH
|
Gail + testosterone
|
Gail + AMH + testosterone
|
|---|
|
Age at menarche, years
| | | | |
0.67%
|
|
< 12
|
1.00 (0.90, 1.11)
|
1.02 (0.91, 1.13)
|
1.00 (0.90, 1.11)
|
1.01 (0.91, 1.12)
| |
|
12–13
|
1.00 (0.90, 1.11)
|
1.01 (0.91, 1.12)
|
1.00 (0.90, 1.11)
|
1.01 (0.91, 1.12)
| |
|
≥ 14
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
| |
|
Age at first live birth, years
| | | | |
18.47%
|
|
< 20
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
| |
|
20–24
|
1.11 (1.00, 1.24)
|
1.12 (1.00, 1.25)
|
1.12 (1.00, 1.26)
|
1.12 (1.00, 1.26)
| |
|
25–29 or nulliparous
|
1.24 (1.11, 1.38)
|
1.25 (1.12, 1.39)
|
1.26 (1.12, 1.41)
|
1.26 (1.13, 1.42)
| |
|
≥ 30
|
1.38 (1.23, 1.54)
|
1.40 (1.25, 1.56)
|
1.41 (1.26, 1.58)
|
1.42 (1.27, 1.60)
| |
|
Number of benign breast biopsies
| | | |
8.13%
|
|
0
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
| |
|
≥ 1
|
1.58 (1.33, 1.88)
|
1.55 (1.31, 1.85)
|
1.59 (1.34, 1.89)
|
1.56 (1.31, 1.86)
| |
|
Number of first-degree family members with breast cancera
|
6.56%
|
|
0
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
|
1.0 (ref)
| |
|
1
|
1.58 (1.32, 1.89)
|
1.57 (1.31, 1.88)
|
1.57 (1.30, 1.88)
|
1.56 (1.30, 1.87)
| |
|
> 1
|
2.49 (2.08, 2.99)
|
2.47 (2.06, 2.96)
|
2.45 (2.04, 2.94)
|
2.43 (2.03, 2.92)
| |
|
AMH
| | | | |
19.38%
|
|
Q1
|
–
|
1.0 (ref)
|
–
|
1.0 (ref)
| |
|
Q2
|
–
|
1.16 (1.04, 1.29)
|
–
|
1.15 (1.03, 1.28)
| |
|
Q3
|
–
|
1.34 (1.20, 1.49)
|
–
|
1.33 (1.19, 1.48)
| |
|
Q4
|
–
|
1.55 (1.39, 1.73)
|
–
|
1.53 (1.37, 1.70)
| |
|
Testosterone
| | | | |
9.48%
|
|
Q1
|
–
|
–
|
1.0 (ref)
|
1.0 (ref)
| |
|
Q2
|
–
|
–
|
1.08 (1.02, 1.15)
|
1.07 (1.00, 1.14)
| |
|
Q3
|
–
|
–
|
1.17 (1.10, 1.25)
|
1.14 (1.07, 1.22)
| |
|
Q4
|
–
|
–
|
1.27 (1.19, 1.35)
|
1.22 (1.15, 1.30)
| |
- aThe number of first-degree family members with breast cancer was coded as either 0, 1, or > 1 affected relatives. For cohorts that collected family history as a no/yes variable, “yes” answers were assigned to the intermediate category (1 affected relative)
- bWe used the method described in Bruzzi et al. [49] to estimate attributable risk for a one-category increase (or decrease for age at menarche) in the risk factor. The Sister study was excluded from attributable risk estimation because all participants had a family history of breast cancer
