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Table 2 Relative risks calculated using random-effects meta-analysis and attributable risk fractions

From: Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model

Risk factor RR estimates Attributable risk (%) for Gail+ AMH + testosterone modelb
Gail Gail + AMH Gail + testosterone Gail + AMH + testosterone
Age at menarche, years      0.67%
 < 12 1.00 (0.90, 1.11) 1.02 (0.91, 1.13) 1.00 (0.90, 1.11) 1.01 (0.91, 1.12)  
 12–13 1.00 (0.90, 1.11) 1.01 (0.91, 1.12) 1.00 (0.90, 1.11) 1.01 (0.91, 1.12)  
 ≥ 14 1.0 (ref) 1.0 (ref) 1.0 (ref) 1.0 (ref)  
Age at first live birth, years      18.47%
 < 20 1.0 (ref) 1.0 (ref) 1.0 (ref) 1.0 (ref)  
 20–24 1.11 (1.00, 1.24) 1.12 (1.00, 1.25) 1.12 (1.00, 1.26) 1.12 (1.00, 1.26)  
 25–29 or nulliparous 1.24 (1.11, 1.38) 1.25 (1.12, 1.39) 1.26 (1.12, 1.41) 1.26 (1.13, 1.42)  
 ≥ 30 1.38 (1.23, 1.54) 1.40 (1.25, 1.56) 1.41 (1.26, 1.58) 1.42 (1.27, 1.60)  
Number of benign breast biopsies     8.13%
 0 1.0 (ref) 1.0 (ref) 1.0 (ref) 1.0 (ref)  
 ≥ 1 1.58 (1.33, 1.88) 1.55 (1.31, 1.85) 1.59 (1.34, 1.89) 1.56 (1.31, 1.86)  
Number of first-degree family members with breast cancera 6.56%
 0 1.0 (ref) 1.0 (ref) 1.0 (ref) 1.0 (ref)  
 1 1.58 (1.32, 1.89) 1.57 (1.31, 1.88) 1.57 (1.30, 1.88) 1.56 (1.30, 1.87)  
 > 1 2.49 (2.08, 2.99) 2.47 (2.06, 2.96) 2.45 (2.04, 2.94) 2.43 (2.03, 2.92)  
AMH      19.38%
 Q1 1.0 (ref) 1.0 (ref)  
 Q2 1.16 (1.04, 1.29) 1.15 (1.03, 1.28)  
 Q3 1.34 (1.20, 1.49) 1.33 (1.19, 1.48)  
 Q4 1.55 (1.39, 1.73) 1.53 (1.37, 1.70)  
Testosterone      9.48%
 Q1 1.0 (ref) 1.0 (ref)  
 Q2 1.08 (1.02, 1.15) 1.07 (1.00, 1.14)  
 Q3 1.17 (1.10, 1.25) 1.14 (1.07, 1.22)  
 Q4 1.27 (1.19, 1.35) 1.22 (1.15, 1.30)  
  1. aThe number of first-degree family members with breast cancer was coded as either 0, 1, or > 1 affected relatives. For cohorts that collected family history as a no/yes variable, “yes” answers were assigned to the intermediate category (1 affected relative)
  2. bWe used the method described in Bruzzi et al. [49] to estimate attributable risk for a one-category increase (or decrease for age at menarche) in the risk factor. The Sister study was excluded from attributable risk estimation because all participants had a family history of breast cancer