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Fig. 7 | Breast Cancer Research

Fig. 7

From: Separation of breast cancer and organ microenvironment transcriptomes in metastases

Fig. 7

Gene Set Enrichment Analyses identify signatures upregulated in metastases. a Gene set enrichment scores for tumors and metastases were identified for 18,026 gene signatures and hierarchical clustered. b >‚ÄČ400 gene sets were found to be upregulated on average in metastases from all six basal-like PDXs, the sum of enrichment scores was identified by adding together the difference in enrichment scores of all 6 PDXs (metastases compared to tumors). c Average enrichment score values for one gene set across different tumors and metastases. d Effect of targeting the most upregulated pathway with three different Src inhibitors on viability of PDX spheroids in suspension culture

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