Fig. 7

Gene Set Enrichment Analyses identify signatures upregulated in metastases. a Gene set enrichment scores for tumors and metastases were identified for 18,026 gene signatures and hierarchical clustered. b > 400 gene sets were found to be upregulated on average in metastases from all six basal-like PDXs, the sum of enrichment scores was identified by adding together the difference in enrichment scores of all 6 PDXs (metastases compared to tumors). c Average enrichment score values for one gene set across different tumors and metastases. d Effect of targeting the most upregulated pathway with three different Src inhibitors on viability of PDX spheroids in suspension culture