Fig. 6
From: Separation of breast cancer and organ microenvironment transcriptomes in metastases
Identification of microenvironment-regulated genes or metastasis-selected genes. a Approach used to compare gene expression profiles of mammary gland tumors (MGT), liver metastases, and MGT which were grown from liver metastases. b Human ID1 gene expression levels in MGT, metastases, and MGT grown from metastases. Most metastases have increased ID1 expression, which reverts to levels observed in parental MGT when the metastases are collected and regrown in the mammary gland. c Shown are examples of genes upregulated in UCD52 liver metastases, which maintained high expression when the liver metastases were collected and grown in the mammary gland