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Table 3 Breast cancer recurrence and all-cause mortality, HR, and 95% CIs associating hypothyroidism status among stage I–III, operable breast cancer women diagnosed from 1996 to 2009 stratified by menopausal status, ER status, and chemo- and radiotherapy

From: Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study

  Prevalent hypothyroidism Incident hypothyroidism
Recurrence Recurrence (counts) HR (95% CI) Recurrence (counts) HR (95% CI)
Crude Adjusted1 Crude Adjusted2
Menopausal status
 Premenopausal 1653 1.00 (0.70–1.43) 1.15 (0.79–1.69) 1622 1.30 (0.91–1.87) 1.24 (0.86–1.78)
 Postmenopausal 4152 0.93 (0.79–1.09) 0.99 (0.83–1.17) 3999 0.87 (0.66–1.16) 0.82 (0.61–1.08)
ER status
 Positive 4236 0.94 (0.79–1.11) 1.00 (0.83–1.19) 4099 0.97 (0.75–1.25) 0.93 (0.71–1.20)
 Negative 1391 1.04 (0.77–1.39) 1.05 (0.76–1.45) 1346 1.08 (0.68–1.73) 1.02 (0.64–1.62)
Chemotherapy3
 Yes 1950 1.01 (0.72–1.50) 0.97 (0.67–1.40)
 No 3676 0.98 (0.74–1.29) 0.91 (0.69–1.21)
Radiotherapy3
 Yes 3643 0.96 (0.73–1.25) 0.91 (0.69–1.20)
 No 1983 1.11 (0.75–1.63) 0.99 (0.67–1.46)
All-cause mortality Mortality (counts) HR (95% CI) Mortality (counts) HR (95% CI)
Crude Adjusted1 Crude Adjusted1
Menopausal status
 Premenopausal 1792 1.03 (0.73–1.47) 1.19 (0.82–1.71) 1760 1.24 (0.94–1.64) 1.15 (0.85–1.55)
 Postmenopausal 8298 1.17 (1.05–1.30) 1.00 (0.89–1.12) 7932 1.13 (0.99–1.29) 1.06 (0.91–1.23)
ER status
 Positive 7418 1.25 (1.11–1.40) 1.00 (0.88–1.13) 7118 1.13 (0.99–1.30) 1.06 (0.91–1.23)
 Negative 2354 1.32 (1.07–1.63) 1.20 (0.95–1.50) 2263 1.27 (0.98–1.64) 1.24 (0.93–1.64)
Chemotherapy
 Yes 2486 1.17 (0.92–1.48) 1.15 (0.90–1.48) 2416 1.18 (0.91–1.51) 1.12 (0.85–1.47)
 No 7608 1.23 (1.11–1.38) 0.98 (0.87–1.11) 7280 1.16 (1.00–1.33) 1.06 (0.91–1.23)
Radiotherapy3
 Yes 5316 1.13 (0.96–1.33) 1.08 (0.90–1.29)
 No 4380 1.22 (1.02–1.46) 1.11 (0.91–1.34)
  1. HR hazard ratio
  2. 1Adjusted for age at diagnosis, menopausal status, UICC stage, histologic grade, ER/ET use, surgery type, receipt of radio- and chemotherapy, comorbidity, and use of simvastatin or aspirin, respectively. 2Adjusted for age at diagnosis, UICC stage, ER/ET use, surgery type, and receipt of chemotherapy. 3Only evaluated for incident hypothyroidism