Table 3 Breast cancer recurrence and all-cause mortality, HR, and 95% CIs associating hypothyroidism status among stage I–III, operable breast cancer women diagnosed from 1996 to 2009 stratified by menopausal status, ER status, and chemo- and radiotherapy

Recurrence

Recurrence (counts)

Recurrence (counts)

Crude

Adjusted¹

Crude

Adjusted²

 Premenopausal

1653

1.00 (0.70–1.43)

1.15 (0.79–1.69)

1622

1.30 (0.91–1.87)

1.24 (0.86–1.78)

 Postmenopausal

4152

0.93 (0.79–1.09)

0.99 (0.83–1.17)

3999

0.87 (0.66–1.16)

0.82 (0.61–1.08)

 Positive

4236

0.94 (0.79–1.11)

1.00 (0.83–1.19)

4099

0.97 (0.75–1.25)

0.93 (0.71–1.20)

 Negative

1391

1.04 (0.77–1.39)

1.05 (0.76–1.45)

1346

1.08 (0.68–1.73)

1.02 (0.64–1.62)

 Yes

–

–

–

1950

1.01 (0.72–1.50)

0.97 (0.67–1.40)

 No

–

–

–

3676

0.98 (0.74–1.29)

0.91 (0.69–1.21)

 Yes

–

–

–

3643

0.96 (0.73–1.25)

0.91 (0.69–1.20)

 No

–

–

–

1983

1.11 (0.75–1.63)

0.99 (0.67–1.46)

All-cause mortality

Mortality (counts)

Mortality (counts)

Crude

Adjusted¹

Crude

Adjusted¹

 Premenopausal

1792

1.03 (0.73–1.47)

1.19 (0.82–1.71)

1760

1.24 (0.94–1.64)

1.15 (0.85–1.55)

 Postmenopausal

8298

1.17 (1.05–1.30)

1.00 (0.89–1.12)

7932

1.13 (0.99–1.29)

1.06 (0.91–1.23)

 Positive

7418

1.25 (1.11–1.40)

1.00 (0.88–1.13)

7118

1.13 (0.99–1.30)

1.06 (0.91–1.23)

 Negative

2354

1.32 (1.07–1.63)

1.20 (0.95–1.50)

2263

1.27 (0.98–1.64)

1.24 (0.93–1.64)

 Yes

2486

1.17 (0.92–1.48)

1.15 (0.90–1.48)

2416

1.18 (0.91–1.51)

1.12 (0.85–1.47)

 No

7608

1.23 (1.11–1.38)

0.98 (0.87–1.11)

7280

1.16 (1.00–1.33)

1.06 (0.91–1.23)

 Yes

–

–

–

5316

1.13 (0.96–1.33)

1.08 (0.90–1.29)

 No

–

–

–

4380

1.22 (1.02–1.46)

1.11 (0.91–1.34)