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Table 2 Multivariable-adjusted hazard ratios (95% CI) for breast cancer-free interval and disease-free survival by tumor AR expression

From: Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer: results from the Breast International Group Trial 1–98

   AR+ vs. AR− 10% increase
Individuals Events HR (95% CI) HR (95% CI)
Breast cancer-free interval
 Model 1a 3021 415 0.84 (0.66–1.07) 0.97 (0.92–1.02)
p = 0.16 p = 0.26
 Model 2b 2907 398 1.07 (0.83–1.39) 1.02 (0.97–1.08)
p = 0.60 p = 0.50
Disease-free survival
 Model 1 3021 676 0.95 (0.78–1.15) 0.97 (0.93–1.01)
p = 0.58 p = 0.19
 Model 2 2907 650 1.12 (0.91–1.38) 1.01 (0.96–1.05)
p = 0.27 p = 0.77
  1. Hazard ratios (HRs) compare AR+ (≥ 1%) to AR− (< 1%) cancers or represent association per each successive 10% increase in AR expression
  2. aModel 1: Stratified by treatment assignment and receipt of chemotherapy, and adjusted for age at randomization
  3. bModel 2: Model 1 + adjusted for tumor size, lymph node involvement, local therapy, ER, PR, HER2, and Ki67 expression