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Fig. 7 | Breast Cancer Research

Fig. 7

From: CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB

Fig. 7

A novel mechanism underlying the contribution of primary cancer to lung metastatic niche formation in breast cancer. Primary cancer-secreted CXCL17 increases the accumulation of CD11b+Gr-1+ MDSCs in the lungs, which produce PDGF-BB, resulting in enhanced angiogenesis in the lung tissue before cancer cells’ arrival. In addition, CXCL17 also drives CD11b+Gr-1+ MDSCs to exhibit supportive activity for cancer extravasation and survival by PDGF-BB production under cancer cell arrival

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Breast Cancer Research

ISSN: 1465-542X

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