Fig. 4
From: Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer
Proposed model explaining the difference of parity-induced protection according to breast cancer subtypes. TP53 has long been recognized as a potential mediator of pregnancy-induced resistance to mammary carcinogenesis. We hypothesize that an early pregnancy might protect less effectively against TP53 mutant premalignant lesion. TP53 mutations are highly linked to the TNBC subtype; this could explain why the pregnancy-induced resistance is lost in TNBC