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Fig. 1 | Breast Cancer Research

Fig. 1

From: Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer

Fig. 1

Imprint of pregnancy and age at first pregnancy on breast cancer biology. a Comparison of somatic SNVs and Indels in tumor between nulliparous (n = 49) and parous (upper) (n = 264) and between early (n = 82) and late parous (bottom) (n = 71). Padj, P values derived from multivariate linear regression analysis adjusted for potential confounders. b Radar plots showing the frequency of somatic driver mutations and somatic driver SNCAs in breast cancer from nulliparous (n = 49) and parous (upper) (n = 264) and between early (n = 82) and late parous (bottom) (n = 71) patients. Significant genes independently associated with parity or age at first pregnancy are highlighted in bold. c Proportion of PAM50 breast cancer subtypes in nulliparous (n = 34) and parous (upper) (n = 148) and in early (n = 51) and late parous (bottom) (n = 45) patients. d Comparison of TIL levels (%) between nulliparous (n = 26) and parous (upper) (n = 134) and between early (n = 47) and late parous (bottom) (n = 38) patients. Padj, P values derived from multivariate linear regression analysis adjusted for potential confounders

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