Table 3 Cox proportional hazards models for RFS, DMFS and OS. All significant clinicopathological variables were included in a multivariate Cox proportional hazards model. Distant disease at diagnosis, nodal status and sTIL infiltration are significantly associated with OS. In the group with initially localised disease, nodal disease was significantly associated with OS and both pCR after NACT and HR status were associated with RFS. *Significant P values in italic

sTIL (> 10%)

0.465

0.266

0.811

0.006

cN stage

1.635

1.137

2.353

0.008

cM stage

3.060

1.794

5.219

< 0.001

HR status

0.631

0.357

1.114

0.11

cN stage

1.354

0.876

2.093

0.17

HR status

0.471

0.249

0.889

0.02

Taxane NACT

0.934

0.424

2.055

0.86

pCR

0.406

0.166

0.992

0.05

cN stage

1.530

0.981

2.39

0.06

HR status

0.564

0.295

1.08

0.08

Taxane NACT

0.771

0.348

1.71

0.52

pCR

0.391

0.149

1.03

0.06

cN stage

1.652

1.020

2.674

0.04

HR status

0.453

0.224

0.918

0.03

Taxane NACT

0.672

0.296

1.524

0.34

pCR

0.368

0.126

1.075

0.07