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Fig. 2 | Breast Cancer Research

Fig. 2

From: MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors

Fig. 2

a–f Effects of transient overexpression or inhibition of miR-1287-5p on cellular growth using colony formation unit (CFU) assay in three different triple negative cell lines. Bar chart graphs represent relative number of colonies in percentage compared to control transfected cells (n = 3) (a, c, and e), representative pictures are shown (b, d, and f). Mir-1287-5p mimics led to a significant decrease in cellular growth, while miR-1287-5p inhibitor exerted the opposite effect. g–h Effect of stable overexpression of miR-1287-5p on cellular growth measured by WST-1 proliferation assay and (i–l) CFU assay in two different triple negative breast cancer cell lines. Stable overexpression of miR-1287-5p led to a significantly reduced cellular growth in the cell lines SUM159 and MDA-MB-231. *p < 0.05, **p < 0.01, ***p < 0.001

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Breast Cancer Research

ISSN: 1465-542X

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