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Table 3 Identified variants in annotated in OncoKB with corresponding targeted therapeutics

From: Targeted mutation detection in breast cancer using MammaSeq™

Sample ID

Gene

Protein sequence change

Allele frequency

Level

Drugs

MET_03

ERBB2

Amplification

1

Lapatinib + trastuzumab, pertuzumab + trastuzumab, ado-trastuzumab emtansine, lapatinib, trastuzumab

MET_33

ERBB2

Amplification

1

MET_39

AKT1

E17K

0.25

3

AZD5363

MET_18

ERBB2

I654V

0.122222

3

Neratinib

MET_32

ERBB2

I654V

0.461731

3

MET_49

ERBB2

I654V

0.495495

3

MET_07

ESR1

D538G

0.477717

3

AZD9496, fulvestrant

MET_21

ESR1

D538G

0.335884

3

MET_28

ESR1

D538G

0.454271

3

MET_27

ESR1

Y537S

0.376441

3

MET_22

PIK3CA

E453K

0.444722

3

Buparlisib, serabelisib, alpelisib + fulvestrant, copanlisib, GDC-0077, alpelisib, taselisib + fulvestrant, buparlisib + fulvestrant, taselisib

MET_10

PIK3CA

E542K

0.106212

3

MET_21

PIK3CA

E542K

0.501912

3

MET_41

PIK3CA

E542K

0.073183

3

MET_49

PIK3CA

E542K

0.467702

3

MET_08

PIK3CA

E545K

0.204327

3

MET_34

PIK3CA

E545K

0.0871914

3

MET_40

PIK3CA

E545K

0.844344

3

MET_25

PIK3CA

H1047R

0.341171

3

MET_29

PIK3CA

H1047R

0.180681

3

MET_32

PIK3CA

H1047R

0.2785

3

MET_33

PIK3CA

H1047R

0.413998

3

MET_38

PIK3CA

H1047R

0.384692

3

MET_44

PIK3CA

H1047R

0.60054

3

MET_06

PIK3CA

N345K

0.376571

3

MET_35

PIK3CA

Q546R

0.435484

3

PR_26

BRAF

G469A

0.52028

4

LTT462, BVD-523, KO-994

MET_34

KRAS

G12D

0.074

4

LY3214996, KO-947, GDC-1014

MET_22

PTEN

C136Y

0.756233

4

AZD6482 + alpelisib

CF_28_Draw_1

ESR1

D538G

0.0746562

3

AZD9496, fulvestrant

CF_28_Draw_5

ESR1

D538G

0.146853

3

CF_22_Draw_1

PIK3CA

H1047R

0.320088

3

Buparlisib, serabelisib, alpelisib + fulvestrant, copanlisib, GDC-0077, alpelisib, taselisib + fulvestrant, buparlisib + fulvestrant, taselisib

CF_22_Draw_2

PIK3CA

H1047R

0.402402

3