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Table 3 Identified variants in annotated in OncoKB with corresponding targeted therapeutics

From: Targeted mutation detection in breast cancer using MammaSeq™

Sample ID Gene Protein sequence change Allele frequency Level Drugs
MET_03 ERBB2 Amplification 1 Lapatinib + trastuzumab, pertuzumab + trastuzumab, ado-trastuzumab emtansine, lapatinib, trastuzumab
MET_33 ERBB2 Amplification 1
MET_39 AKT1 E17K 0.25 3 AZD5363
MET_18 ERBB2 I654V 0.122222 3 Neratinib
MET_32 ERBB2 I654V 0.461731 3
MET_49 ERBB2 I654V 0.495495 3
MET_07 ESR1 D538G 0.477717 3 AZD9496, fulvestrant
MET_21 ESR1 D538G 0.335884 3
MET_28 ESR1 D538G 0.454271 3
MET_27 ESR1 Y537S 0.376441 3
MET_22 PIK3CA E453K 0.444722 3 Buparlisib, serabelisib, alpelisib + fulvestrant, copanlisib, GDC-0077, alpelisib, taselisib + fulvestrant, buparlisib + fulvestrant, taselisib
MET_10 PIK3CA E542K 0.106212 3
MET_21 PIK3CA E542K 0.501912 3
MET_41 PIK3CA E542K 0.073183 3
MET_49 PIK3CA E542K 0.467702 3
MET_08 PIK3CA E545K 0.204327 3
MET_34 PIK3CA E545K 0.0871914 3
MET_40 PIK3CA E545K 0.844344 3
MET_25 PIK3CA H1047R 0.341171 3
MET_29 PIK3CA H1047R 0.180681 3
MET_32 PIK3CA H1047R 0.2785 3
MET_33 PIK3CA H1047R 0.413998 3
MET_38 PIK3CA H1047R 0.384692 3
MET_44 PIK3CA H1047R 0.60054 3
MET_06 PIK3CA N345K 0.376571 3
MET_35 PIK3CA Q546R 0.435484 3
PR_26 BRAF G469A 0.52028 4 LTT462, BVD-523, KO-994
MET_34 KRAS G12D 0.074 4 LY3214996, KO-947, GDC-1014
MET_22 PTEN C136Y 0.756233 4 AZD6482 + alpelisib
CF_28_Draw_1 ESR1 D538G 0.0746562 3 AZD9496, fulvestrant
CF_28_Draw_5 ESR1 D538G 0.146853 3
CF_22_Draw_1 PIK3CA H1047R 0.320088 3 Buparlisib, serabelisib, alpelisib + fulvestrant, copanlisib, GDC-0077, alpelisib, taselisib + fulvestrant, buparlisib + fulvestrant, taselisib
CF_22_Draw_2 PIK3CA H1047R 0.402402 3