From: Targeted mutation detection in breast cancer using MammaSeq™
Sample ID | Gene | Protein sequence change | Allele frequency | Level | Drugs |
---|---|---|---|---|---|
MET_03 | ERBB2 | Amplification | – | 1 | Lapatinib + trastuzumab, pertuzumab + trastuzumab, ado-trastuzumab emtansine, lapatinib, trastuzumab |
MET_33 | ERBB2 | Amplification | – | 1 | |
MET_39 | AKT1 | E17K | 0.25 | 3 | AZD5363 |
MET_18 | ERBB2 | I654V | 0.122222 | 3 | Neratinib |
MET_32 | ERBB2 | I654V | 0.461731 | 3 | |
MET_49 | ERBB2 | I654V | 0.495495 | 3 | |
MET_07 | ESR1 | D538G | 0.477717 | 3 | AZD9496, fulvestrant |
MET_21 | ESR1 | D538G | 0.335884 | 3 | |
MET_28 | ESR1 | D538G | 0.454271 | 3 | |
MET_27 | ESR1 | Y537S | 0.376441 | 3 | |
MET_22 | PIK3CA | E453K | 0.444722 | 3 | Buparlisib, serabelisib, alpelisib + fulvestrant, copanlisib, GDC-0077, alpelisib, taselisib + fulvestrant, buparlisib + fulvestrant, taselisib |
MET_10 | PIK3CA | E542K | 0.106212 | 3 | |
MET_21 | PIK3CA | E542K | 0.501912 | 3 | |
MET_41 | PIK3CA | E542K | 0.073183 | 3 | |
MET_49 | PIK3CA | E542K | 0.467702 | 3 | |
MET_08 | PIK3CA | E545K | 0.204327 | 3 | |
MET_34 | PIK3CA | E545K | 0.0871914 | 3 | |
MET_40 | PIK3CA | E545K | 0.844344 | 3 | |
MET_25 | PIK3CA | H1047R | 0.341171 | 3 | |
MET_29 | PIK3CA | H1047R | 0.180681 | 3 | |
MET_32 | PIK3CA | H1047R | 0.2785 | 3 | |
MET_33 | PIK3CA | H1047R | 0.413998 | 3 | |
MET_38 | PIK3CA | H1047R | 0.384692 | 3 | |
MET_44 | PIK3CA | H1047R | 0.60054 | 3 | |
MET_06 | PIK3CA | N345K | 0.376571 | 3 | |
MET_35 | PIK3CA | Q546R | 0.435484 | 3 | |
PR_26 | BRAF | G469A | 0.52028 | 4 | LTT462, BVD-523, KO-994 |
MET_34 | KRAS | G12D | 0.074 | 4 | LY3214996, KO-947, GDC-1014 |
MET_22 | PTEN | C136Y | 0.756233 | 4 | AZD6482 + alpelisib |
CF_28_Draw_1 | ESR1 | D538G | 0.0746562 | 3 | AZD9496, fulvestrant |
CF_28_Draw_5 | ESR1 | D538G | 0.146853 | 3 | |
CF_22_Draw_1 | PIK3CA | H1047R | 0.320088 | 3 | Buparlisib, serabelisib, alpelisib + fulvestrant, copanlisib, GDC-0077, alpelisib, taselisib + fulvestrant, buparlisib + fulvestrant, taselisib |
CF_22_Draw_2 | PIK3CA | H1047R | 0.402402 | 3 |