- Localized density based on a visual assessment of the site in the prior negative screening corresponding to subsequent tumor location, categorized according to the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) lexicon, fifth edition. Overall density was categorized into high and low based on the cut-point (18%) representing the transition from BI-RADS category B to C
- *Tumor size was based on post-operative specimen pathology assessment; missing for 8 cases
- **Adjusted for age, menopausal status, body mass index, age at menarche, alcohol use, parity, use of hormone replacement therapy, use of oral contraceptives, family history, and benign breast disease
