- Localized density based on a visual assessment of the site in the prior negative screening corresponding to subsequent tumor location, categorized according to the definitions in the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) lexicon, fifth edition. Overall density was categorized into high and low based on the cut-point (18%) representing the transition from BI-RADS category B to C
- *Tumor size was based on post-operative specimen pathology assessment; missing for 8 cases
- **Adjusted for age, menopausal status, body mass index, age at menarche, alcohol use, parity, use of hormone replacement therapy, use of oral contraceptives, family history, and benign breast disease