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Fig. 7 | Breast Cancer Research

Fig. 7

From: Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells

Fig. 7

MDMX and MDM2 in TNBC promote metastasis, and in ERα+ breast cancer MDM2 promotes proliferation. In TNBC, MDMX promotes expression of CXCR4 and PTGS2 with associated release of CTCs but no increase in cell proliferation. In ERα+ breast cancer, estrogen stimulates MDM2 expression with no influence on CXCR4 and causes an increase in cell proliferation without correlated metastasis

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