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Fig. 6 | Breast Cancer Research

Fig. 6

From: Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells

Fig. 6

Comparative levels of CXCR4 in ERα+ T47D and TNBC MDA-MB-231 tumors. a CXCR4 RNA expression normalized to gapdh with MDM2 knockdown was determined using real-time qRT-PCR. 231.mir30.vector (n = 6), T47D.mir30.vector (n = 10), and T47D.shmdm2 (n = 9) tumor samples were analyzed. The RNA level of CXCR4 was set as 1 for the 231.mir30.vector group, and T47D samples were expressed relative to 231.mir30.vector values. b Protein expression of CXCR4 was compared from parental cell lines and two tumors from each group. Representative Western blot demonstrating protein levels of CXCR4 and actin in MDA-MB-231 and T47D groups shown using two gels (lanes 1–9 and 10–16, with tumor 2 for 231.shmdmx used in lane 10 as a common reference)

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