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Table 2 Prevalence of BRCA1-like phenotype in the large-scale breast cancer cohorts, TCGA and METABRIC

From: Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier

  TCGA METABRIC
BRCA1-like non-BRCA1-like P value § BRCA1-like non-BRCA1-like P value §
n 308 649   343 1625  
Age, years (mean (sd)) 56.57 (13.26) 59.33 (13.06) 0.002 56.74 (13.93) 62.02 (12.56) < 0.001
Stage (%)    0.22    0.35
 Stage I-II 238 (77.3) 473 (72.9)   220 (64.1) 1106 (68.1)  
 Stage III-IV 63 (20.5) 165 (25.4)   26 (7.6) 102 (6.3)  
 (Missing) 7 (2.3) 11 (1.7)   97 (28.3) 417 (25.7)  
ER (%)    < 0.001    < 0.001
 Positive 129 (41.9) 575 (88.6)   108 (31.5) 1393 (85.7)  
 Negative 166 (53.9) 43 (6.6)   235 (68.5) 232 (14.3)  
 (Missing) 13 (4.2) 31 (4.8)   0 (0.0) 0 (0.0)  
PR (%)    < 0.001    < 0.001
 Positive 97 (31.5) 514 (79.2)   57 (16.6) 980 (60.3)  
 Negative 195 (63.3) 104 (16.0)   286 (83.4) 645 (39.7)  
 NA 16 (5.2) 31 (4.8)   0 (0.0) 0 (0.0)  
HER2 (%)    0.59    0.98
 Positive 50 (16.2) 93 (14.3)   43 (12.5) 200 (12.3)  
 Negative 161 (52.3) 333 (51.3)   300 (87.5) 1425 (87.7)  
 (Missing) 97 (31.5) 223 (34.4)   0 (0.0) 0 (0.0)  
Any ER, PR, or HER2 positivity (%)    < 0.001    < 0.001
 Yes 159 (51.6) 595 (91.7)   143 (41.7) 1508 (92.8)  
 No 88 (28.6) 12 (1.8)   200 (58.3) 117 (7.2)  
 Cannot be determined 61 (19.8) 42 (6.5)   0 (0.0) 0 (0.0)  
  1. TCGA The Cancer Genome Atlas, METABRIC Molecular Taxonomy of Breast Cancer International Consortium, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2
  2. §For any continuous measure (i.e. age), the two-tailed t-test was used. For any categorical measure, the two-tailed Fisher’s exact test was used