Fig. 4

Differential DNA methylation in groups with BRCA1-like tumors relative to groups with non-BRCA1-like tumors defined by the support vector machine (SVM) BRCA1-like classifier among hormone-receptor-positive tumors in The Cancer Genome Atlas (TCGA). a Genomic context enrichment analysis of hypermethylated and hypomethylated CpGs. Solid dots and horizontal segments indicate odds ratios and 95% confidence intervals. P values were from the two-tailed Fisher’s exact test. b Correlation of the Horvath methylation age (“epigenetic clock”) with patient chronological age, colored by BRCA1-like status. c Comparison of chronological age or the Horvath methylation age between BRCA1-like and non-BRCA1-like hormone-receptor-positive tumors. P value indicates statistical significance from the covariate-adjusted linear model. n.s., not significant