Impact of obesity on breast cancer recurrence and minimal residual disease

Ecker, Brett L.; Lee, Jun Y.; Sterner, Christopher J.; Solomon, Aaron C.; Pant, Dhruv K.; Shen, Fei; Peraza, Javier; Vaught, Lauren; Mahendra, Samyukta; Belka, George K.; Pan, Tien-chi; Schmitz, Kathryn H.; Chodosh, Lewis A.

doi:10.1186/s13058-018-1087-7

Breast Cancer Research

Table 1 Serum biomarkers of diet-induced obesity (n = 10/arm)

From: Impact of obesity on breast cancer recurrence and minimal residual disease

	LFD	p Value^a vs. HFD-Obese	HFD-Lean	p Value^b vs. HFD-Obese	HFD-Obese	p Value^c across arms
Sex hormones
Estradiol, pg/ml	5.46 [4.97–6.49]	0.190	4.82 [4.22–7.55]	0.739	4.81 [4.4–5.83]	0.474
Testosterone, ng/ml	0.492 [0.161–0.754]	0.463	0.466 [0.124–7.17]	0.876	0.227 [0.197–0.44]	0.769
SHBG, μg/ml	1.3 [1.08–303]	0.631	24.7 [1.44–332]	0.529	9.65 [1.15–316]	0.416
Adipokines
Leptin, pg/ml	5630 [3190–8070]	< 0.001	6940 [4250–12,100]	< 0.001	18,100 [11,800–20,900]	< 0.001
Adiponectin, ng/ml	12.6 [11.6–14.1]	0.190	14.7 [13.4–17.9]	0.002	12.2 [9.96–13]	0.006
Resistin, pg/ml	5410 [3640–6690]	0.004	5640 [3600–7780]	0.023	9250 [6950–12,400]	0.012
Inflammatory markers
TNF-α, pg/ml	9.86 [5.67–12.5]	0.268	11.6 [10.1–14.5]	0.918	12.5 [8.33–15.2]	0.287
IL-6, pg/ml	4.58 [2.13–5.94]	0.536	0.548 [0.387–1.13]	0.083	1.88 [0.316–11.6]	0.035
MCP-1, pg/ml	39.3 [36.9–41.9]	0.094	38.7 [31.1–53.2]	0.202	64.4 [40.2–93.2]	0.175
CRP, ng/ml	18.2 [15.3–19.4]	0.286	16.9 [15.2–18.1]	0.421	15.7 [15–18]	0.334
tPAI-1, pg/ml	12,200 [8650–16,200]	0.739	11,900 [9480–14,900]	0.481	13,900 [8580–17,500]	0.774
Corticosterone, ng/ml	110 [72.5–164]	0.315	200 [85.2–304]	0.796	199 [75.3–223]	0.379
HGF, pg/ml	9910 [7860–10,800]	0.280	9370 [7600–11,900]	0.247	8520 [6210–10,300]	0.384
Insulin/IGF-1 signaling
Insulin, pg/ml	359 [216–625]	0.481	161 [117–245]	0.011	426 [228–840]	0.020
IGF-1, ng/ml	462 [417–542]	< 0.001	542 [518–609]	0.280	581 [559–617]	0.002
IGFBP1, ng/ml	7.12 [4.35–11.5]	0.064	5.16 [4.1–9.01]	0.436	4.37 [3.32–7.02]	0.170
IGFBP2, ng/ml	145 [107–184]	0.912	224 [155–292]	0.019	148 [105–176]	0.057
IGFBP3, ng/ml	204 [191–213]	0.579	197 [176–223]	0.912	193 [176–228]	0.836
IGFBP5, ng/ml	12.7 [0.811–18.8]	0.345	6.97 [0.861–18.9]	0.579	3.99 [0.818–10.4]	0.607
IGFBP6, ng/ml	206 [180–216]	0.105	224 [196–283]	0.684	223 [200–254]	0.121
IGFBP7, ng/ml	18.2 [16.4–21.6]	0.393	19.2 [16.3–23]	0.684	20.5 [17.7–22.5]	0.673
IGF1/IGFBP1	69.7 [42.6–109]	0.029	111 [62.5–138]	0.393	131 [92.6–197]	0.079
IGF1/IGFBP2	3.51 [2.52–4.7]	0.218	2.5 [1.83–4.03]	0.029	4.01 [3.2–5.64]	0.061
IGF1/IGFBP3	2.4 [2.06–2.64]	0.005	2.81 [2.59–3.05]	0.631	3.02 [2.56–3.33]	0.005
IGF1/IGFBP5	41.2 [22.7–574]	0.075	94.1 [39.6–673]	0.353	501 [77.8–703]	0.171
IGF1/IGFBP6	2.39 [2.08–2.61]	0.247	2.38 [2.04–2.94]	0.436	2.84 [2.18–3.17]	0.475
IGF1/IGFBP7	26.2 [22.7–29.4]	0.280	28 [25.1–33.7]	1.000	29.7 [22.9–35]	0.394

Abbreviations: CRP C-reactive protein, HFD High-fat diet, HGF Hepatocyte growth factor, IGF Insulin-like growth factor, IGFBP Insulin-like growth factor-binding protein, IL Interleukin, LFD Low-fat diet, MCP Monocyte chemoattractant protein, SHBG Sex hormone-binding globulin, TNF-α Tumor necrosis factor-α, tPAI1 Tissue plasminogen activator inhibitor 1
Values represent medians [95% CI]. Bold indicates statistical significance (p ≤ 0.05)
^aMann-Whitney U test between LFD and HFD-Obese
^bMann-Whitney U test between HFD-Lean and HFD-Obese
^cKruskal-Wallis test across three arms

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