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Table 3 For interval breast cancer, marginal odds ratios, area under the receiver operating characteristic curve (AUC) and log likelihood (LL) for Cumulus, Altocumulus and Cirrocumulus measures of dense area and percent density, adjusted for age and body mass index (BMI)

From: Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds

   Dense area   Percent density
OR (95% CI)a OR (95% CI)a
Cumulus Q1 = 20b 10
Q2 = 29 1.53 (0.81–2.89) 26 2.51 (1.14–5.52)
Q3 = 41 2.09 (1.14–3.85) 41 5.11 (2.37–11.1)
Q4 = 78 4.34 (2.43–7.73) 91 10.4 (4.98–21.8)
OPERA 1.84 (1.50–2.26)   2.33 (1.85–2.92)
AUC (95%CI)c 0.70 (0.65–0.74)   0.75 (0.70–0.79)
LL − 206.95   − 192.48
Altocumulus 24 18
25 1.06 (0.57–1.98) 22 1.25 (0.62–2.50)
49 1.82 (1.04–3.18) 48 2.73 (1.46–5.09)
70 3.09 (1.78–5.36) 80 4.74 (2.57–8.72)
OPERA 1.65 (1.35–2.00)   1.92 (1.55–2.36)
AUC (95% CI)c 0.67 (0.63–0.72)   0.70 (0.66–0.75)
LL − 212.59   − 204.60
Cirrocumulus 18 15
31 1.47 (0.75–2.88) 29 1.78 (0.90–3.51)
39 2.33 (1.21–4.49) 40 3.37 (1.71–6.66)
80 4.64 (2.51–8.58) 84 6.56 (3.44–12.5)
OPERA 1.84 (1.51–2.25)   2.06 (1.67–2.54)
AUC (95% CI)c 0.70 (0.66–0.75)   0.73 (0.68–0.77)
LL − 205.43   − 198.45
  1. Odds ratios (OR) are shown by quartiles (number of cases shown in parentheses)
  2. OPERA change in OR per adjusted standard deviation, CI confidence interval
  3. aOdds ratio per standard deviation adjusted for age and BMI
  4. bQuartiles (Q1–Q4) defined by distribution of the measure adjusted for age, BMI and number of livebirths
  5. cAUCs for mammographic measurements after adjusting for age and BMI