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Table 3 For interval breast cancer, marginal odds ratios, area under the receiver operating characteristic curve (AUC) and log likelihood (LL) for Cumulus, Altocumulus and Cirrocumulus measures of dense area and percent density, adjusted for age and body mass index (BMI)

From: Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds

  

Dense area

 

Percent density

OR (95% CI)a

OR (95% CI)a

Cumulus

Q1 = 20b

–

10

–

Q2 = 29

1.53 (0.81–2.89)

26

2.51 (1.14–5.52)

Q3 = 41

2.09 (1.14–3.85)

41

5.11 (2.37–11.1)

Q4 = 78

4.34 (2.43–7.73)

91

10.4 (4.98–21.8)

OPERA

1.84 (1.50–2.26)

 

2.33 (1.85–2.92)

AUC (95%CI)c

0.70 (0.65–0.74)

 

0.75 (0.70–0.79)

LL

− 206.95

 

− 192.48

Altocumulus

24

–

18

–

25

1.06 (0.57–1.98)

22

1.25 (0.62–2.50)

49

1.82 (1.04–3.18)

48

2.73 (1.46–5.09)

70

3.09 (1.78–5.36)

80

4.74 (2.57–8.72)

OPERA

1.65 (1.35–2.00)

 

1.92 (1.55–2.36)

AUC (95% CI)c

0.67 (0.63–0.72)

 

0.70 (0.66–0.75)

LL

− 212.59

 

− 204.60

Cirrocumulus

18

–

15

–

31

1.47 (0.75–2.88)

29

1.78 (0.90–3.51)

39

2.33 (1.21–4.49)

40

3.37 (1.71–6.66)

80

4.64 (2.51–8.58)

84

6.56 (3.44–12.5)

OPERA

1.84 (1.51–2.25)

 

2.06 (1.67–2.54)

AUC (95% CI)c

0.70 (0.66–0.75)

 

0.73 (0.68–0.77)

LL

− 205.43

 

− 198.45

  1. Odds ratios (OR) are shown by quartiles (number of cases shown in parentheses)
  2. OPERA change in OR per adjusted standard deviation, CI confidence interval
  3. aOdds ratio per standard deviation adjusted for age and BMI
  4. bQuartiles (Q1–Q4) defined by distribution of the measure adjusted for age, BMI and number of livebirths
  5. cAUCs for mammographic measurements after adjusting for age and BMI