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Table 3 Self-reported change in neurotoxicity scores by tertiles of monthly servingsa of fruit and vegetable during treatment (FACT/GOG-Ntx subscale) (n = 900)

From: Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

Food group

Total

< 10%a

10–30%b

> 30%b

p value c

All fruits

    

0.81

 ≤ 30.8

300 (33.3)

96 (34.2)

100 (32.7)

104 (33.2)

 

 30.9–69.5

303 (33.7)

88 (31.3)

103 (33.7)

112 (35.8)

 

 > 69.5

297 (33.0)

97 (34.5)

103 (33.7)

97 (31.0)

 

 Citrus fruits

    

0.38

  ≤ 2.5

308 (34.2)

100 (35.6)

109 (35.6)

99 (31.6)

 

  2.6–14.5

311 (34.6)

101 (35.9)

94 (30.7)

116 (37.1)

 

  > 14.5

281 (31.2)

80 (28.5)

103 (33.7)

98 (31.3)

 

 Other fruits

    

0.74

  ≤ 22.8

300 (33.3)

91 (32.4)

97 (31.7)

112 (35.8)

 

  22.9–53.0

300 (33.3)

94 (33.5)

109 (35.6)

97 (31.0)

 

  > 53.0

300 (33.3)

96 (34.2)

100 (32.7)

104 (33.2)

 

All vegetables

    

0.57

 ≤ 39.8

302 (33.6)

93 (33.1)

99 (32.4)

110 (35.1)

 

 39.9–76.0

300 (33.3)

103 (36.7)

100 (32.7)

97 (31.0)

 

 > 76.0

298 (33.1)

85 (30.3)

107 (35.0)

106 (33.9)

 

 Dark green

    

0.14

  ≤3.8

276 (30.7)

85 (30.3)

88 (28.8)

103 (32.9)

 

  3.9–12.0

333 (37.0)

103 (36.7)

105 (34.3)

125 (39.9)

 

  > 12.0

291 (32.33)

93 (33.1)

113 (36.9)

85 (27.2)

 

 Red/orange

    

0.49

  ≤ 8.0

316 (35.1)

97 (34.5)

99 (32.4)

120 (38.3)

 

  8.1–20.5

291 (32.3)

97 (34.5)

100 (32.7)

94 (30.0)

 

  > 20.5

293 (32.6)

87 (31.0)

107 (35.0)

99 (31.6)

 

 Starchy

    

0.36

  ≤ 5.3

306 (34.0)

88 (31.3)

100 (32.7)

118 (37.7)

 

  5.4–11.0

299 (33.2)

102 (36.3)

105 (34.3)

92 (29.4)

 

  > 11.0

295 (32.8)

91 (32.4)

101 (33.0)

103 (32.9)

 

 Cruciferous

    

0.79

  ≤ 2.5

334 (37.1)

97 (34.5)

119 (38.9)

118 (37.7)

 

  2.6–6.5

275 (30.6)

93 (33.1)

89 (29.1)

93 (29.7)

 

  > 6.5

291 (32.3)

91 (32.4)

98 (32.0)

102 (32.6)

 

 Beans/bean dishes

    

0.74

  ≤ 0.5

336 (37.3)

105 (37.4)

106 (34.6)

125 (39.9)

 

  0.6–2.5

284 (31.6)

89 (31.7)

99 (32.4)

96 (30.7)

 

  > 2.5

280 (31.1)

87 (31.0)

101 (33.0)

92 (29.4)

 

 Other vegetables

    

0.34

  ≤ 8.0

301 (33.4)

98 (34.9)

93 (30.4)

110 (35.1)

 

  8.1–20.5

305 (33.9)

97 (34.5)

114 (37.3)

94 (30.0)

 

  > 20.5

294 (32.7)

86 (30.6)

99 (32.4)

109 (34.8)

 
  1. Data presented as N (%)
  2. FACT/GOG-Ntx Functional Assessment of Cancer Treatment Gynecologic Oncology Group—Neurotoxicity
  3. aServing size based on United States Department of Agriculture portion sizes
  4. bPercent increase in neuropathy severity (based on self-reported score)
  5. cChi-square (α = 0.05)