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Table 3 Self-reported change in neurotoxicity scores by tertiles of monthly servingsa of fruit and vegetable during treatment (FACT/GOG-Ntx subscale) (n = 900)

From: Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

Food group Total < 10%a 10–30%b > 30%b p value c
All fruits      0.81
 ≤ 30.8 300 (33.3) 96 (34.2) 100 (32.7) 104 (33.2)  
 30.9–69.5 303 (33.7) 88 (31.3) 103 (33.7) 112 (35.8)  
 > 69.5 297 (33.0) 97 (34.5) 103 (33.7) 97 (31.0)  
 Citrus fruits      0.38
  ≤ 2.5 308 (34.2) 100 (35.6) 109 (35.6) 99 (31.6)  
  2.6–14.5 311 (34.6) 101 (35.9) 94 (30.7) 116 (37.1)  
  > 14.5 281 (31.2) 80 (28.5) 103 (33.7) 98 (31.3)  
 Other fruits      0.74
  ≤ 22.8 300 (33.3) 91 (32.4) 97 (31.7) 112 (35.8)  
  22.9–53.0 300 (33.3) 94 (33.5) 109 (35.6) 97 (31.0)  
  > 53.0 300 (33.3) 96 (34.2) 100 (32.7) 104 (33.2)  
All vegetables      0.57
 ≤ 39.8 302 (33.6) 93 (33.1) 99 (32.4) 110 (35.1)  
 39.9–76.0 300 (33.3) 103 (36.7) 100 (32.7) 97 (31.0)  
 > 76.0 298 (33.1) 85 (30.3) 107 (35.0) 106 (33.9)  
 Dark green      0.14
  ≤3.8 276 (30.7) 85 (30.3) 88 (28.8) 103 (32.9)  
  3.9–12.0 333 (37.0) 103 (36.7) 105 (34.3) 125 (39.9)  
  > 12.0 291 (32.33) 93 (33.1) 113 (36.9) 85 (27.2)  
 Red/orange      0.49
  ≤ 8.0 316 (35.1) 97 (34.5) 99 (32.4) 120 (38.3)  
  8.1–20.5 291 (32.3) 97 (34.5) 100 (32.7) 94 (30.0)  
  > 20.5 293 (32.6) 87 (31.0) 107 (35.0) 99 (31.6)  
 Starchy      0.36
  ≤ 5.3 306 (34.0) 88 (31.3) 100 (32.7) 118 (37.7)  
  5.4–11.0 299 (33.2) 102 (36.3) 105 (34.3) 92 (29.4)  
  > 11.0 295 (32.8) 91 (32.4) 101 (33.0) 103 (32.9)  
 Cruciferous      0.79
  ≤ 2.5 334 (37.1) 97 (34.5) 119 (38.9) 118 (37.7)  
  2.6–6.5 275 (30.6) 93 (33.1) 89 (29.1) 93 (29.7)  
  > 6.5 291 (32.3) 91 (32.4) 98 (32.0) 102 (32.6)  
 Beans/bean dishes      0.74
  ≤ 0.5 336 (37.3) 105 (37.4) 106 (34.6) 125 (39.9)  
  0.6–2.5 284 (31.6) 89 (31.7) 99 (32.4) 96 (30.7)  
  > 2.5 280 (31.1) 87 (31.0) 101 (33.0) 92 (29.4)  
 Other vegetables      0.34
  ≤ 8.0 301 (33.4) 98 (34.9) 93 (30.4) 110 (35.1)  
  8.1–20.5 305 (33.9) 97 (34.5) 114 (37.3) 94 (30.0)  
  > 20.5 294 (32.7) 86 (30.6) 99 (32.4) 109 (34.8)  
  1. Data presented as N (%)
  2. FACT/GOG-Ntx Functional Assessment of Cancer Treatment Gynecologic Oncology Group—Neurotoxicity
  3. aServing size based on United States Department of Agriculture portion sizes
  4. bPercent increase in neuropathy severity (based on self-reported score)
  5. cChi-square (α = 0.05)