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Fig. 3 | Breast Cancer Research

Fig. 3

From: Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics

Fig. 3

Extensive extramedullary haematopoiesis in the liver during cancer progression in a murine model of 4T1 metastatic breast cancer. Normal liver in the control group (a). The progressive increase in the area of hematopoietic centres in the liver during 4T1 metastatic breast cancer progression (b–e). Small island of extramedullary haematopoiesis in the vicinity of blood vessel walls (first week after 4T1 cell inoculation) (b); increase of hematopoietic centre size near blood vessels and formation of new foci in the liver parenchyma, visible features of proliferation and initial stages of cell differentiation (second week after 4T1 cell inoculation) (c); formation of numerous hematopoietic centres in liver tissue, both in the vicinity of vascular walls and in liver parenchyma, visible cells in different and late stages of differentiation (third week after 4T1 cell inoculation) (d); further increase in number and size of hematopoietic centres, visible variation in the type of produced leucocytes, in the winded sinusoids, numerous leucocytes, among which also immature leucocytes are visible (fourth week after 4T1 cell inoculstion) (e)

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Breast Cancer Research

ISSN: 1465-542X

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