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Fig. 1 | Breast Cancer Research

Fig. 1

From: Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics

Fig. 1

Primary tumour growth and development of pulmonary metastasis in a murine model of 4T1 metastatic breast cancer. Primary tumour growth: weight (a) and volume (b) of primary tumour. Lung metastasis is expressed as the number of metastatic nodules (c). Empty bars represent control animals, and black bars represent tumour-bearing mice. Occurrence of systemic inflammation is expressed as the increase of spleen weight (d). Data are expressed as mean ± SEM (n = 10 for organ weight and n = 4 for lung metastatic nodules). Based on the normality of distribution and variance homogeneity (F test), data were analysed by analysis of variance followed by Tukey’s post hoc test with statistical significance set at *p < 0.05, **p < 0.01, ***p < 0.001

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