Fig. 9From: The isomiR-140-3p-regulated mevalonic acid pathway as a potential target for prevention of triple negative breast cancerAspirin and metformin overcome adaptive resistance of MCF10.AT1-R cells. a, b Images and quantification of the clonogenic survival assay, showing reduction in the number of colonies formed by MCF10.AT1-R cells treated with fluvastatin alone (flu (a))or fluvastatin (FV (b)) in combination with aspirin or metformin relative to vehicle control. Colonies ≥2 mm were scored and tabulated. Values represent average number of colonies ± SEM. Drug combinations are compared to fluvastatin alone and are significantly different; **p < 0.01, ***p < 0.001Back to article page