From: Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts
France | Italy | Spain | UK | Netherlands | Greece | Germany | Sweden | Denmark | Norway | Total | |
---|---|---|---|---|---|---|---|---|---|---|---|
n = 68,707 | n = 27,851 | n = 20,298 | n = 35,349 | n =22,601 | n = 11337 | n = 22,085 | n = 9142 | n = 29,309 | n = 3,4651 | n = 281,330 | |
Menopausal status: | |||||||||||
Premenopausal | 54.0 | 49.4 | 54.0 | 46.4 | 39.1 | 35.0 | 48.6 | 61.7 | 22.6 | 69.5 | 48.5 |
Postmenopausal | 46.0 | 50.6 | 46.0 | 53.6 | 60.9 | 65.0 | 51.4 | 38.3 | 77.4 | 30.5 | 51.5 |
Age at menopause, years: | |||||||||||
≤ 45.0 | 9.7 | 19.1 | 26.1 | 19.5 | 22.6 | 30.7 | 18.3 | 10.6 | 16.8 | 10.4 | 17.2 |
45.1–50.0 | 20.4 | 43.9 | 39.1 | 29.2 | 35.6 | 36.0 | 33.6 | 32.7 | 33.5 | 22.5 | 30.9 |
50.1–55.0 | 21.7 | 28.3 | 28.0 | 22.2 | 29.2 | 26.2 | 26.2 | 18.2 | 27.5 | 9.9 | 24.1 |
> 55.0 | 3.5 | 2.5 | 2.8 | 3.2 | 3.2 | 2.5 | 3.0 | 3.1 | 3.9 | 0.0 | 3.0 |
Missinga | 44.7 | 6.2 | 4.0 | 26 | 9.4 | 4.6 | 20 | 35.4 | 18.3 | 57.2 | 24.8 |
FTP: | |||||||||||
0 (no) | 9.0 | 12.1 | 9.8 | 15.5 | 13.2 | 8.6 | 13.5 | 4.5 | 11.6 | 8.5 | 10.9 |
1 (yes) | 83.8 | 86.6 | 89.4 | 80.8 | 85.5 | 90.8 | 86.2 | 57.4 | 88.0 | 91.5 | 85.2 |
Missing | 7.2 | 1.3 | 0.8 | 3.7 | 1.3 | 0.6 | 0.3 | 38.1 | 0.4 | 0.0 | 3.9 |
Number of FTP: | |||||||||||
1 | 18.4 | 24.9 | 9.1 | 15.6 | 6.9 | 11.3 | 29.6 | 13.8 | 17.7 | 13.3 | 16.8 |
2 | 49.4 | 49.9 | 37.4 | 49.9 | 31.3 | 55.2 | 49.2 | 47.4 | 51.4 | 49.2 | 47.5 |
≥ 3 | 32.2 | 25.2 | 53.5 | 34.3 | 33.3 | 33.4 | 21.2 | 37.9 | 30.9 | 37.5 | 33.3 |
Missingb | 0.0 | 0.0 | 0.0 | 0.2 | 28.5 | 0.1 | 0.0 | 0.9 | 0.0 | 0.0 | 2.4 |
Age at 1st FTP, years: | |||||||||||
≤ 20 | 9.8 | 8.7 | 10.4 | 11.8 | 10.0 | 23.3 | 20.2 | 17.1 | 23.6 | 21.5 | 14.6 |
20.1–25.0 | 53.1 | 43.6 | 52.2 | 42.2 | 45.1 | 41.5 | 47.3 | 45.5 | 46.4 | 45.9 | 47.3 |
25.1–30.0 | 27.8 | 34.6 | 30.3 | 31.8 | 34.8 | 25.0 | 23.1 | 25.9 | 22.5 | 23.6 | 28.1 |
31.1–35.0 | 7.0 | 10.2 | 5.5 | 10.1 | 7.9 | 6.8 | 7.1 | 6.2 | 5.0 | 6.8 | 7.4 |
> 35.0 | 2.0 | 2.7 | 1.5 | 3.6 | 2.2 | 2.3 | 2.2 | 1.6 | 1.3 | 2.2 | 2.2 |
Missingb | 0.3 | 0.2 | 0.1 | 0.5 | 0.0 | 1.1 | 0.1 | 3.7 | 1.2 | 0.0 | 0.4 |
Breastfeeding, months: | |||||||||||
0 | 27.7 | 16.8 | 11.2 | 15.8 | 13.6 | 11.1 | 16.9 | 0 | 6.9 | 5.7 | 15.5 |
0.1–6.0 | 47.2 | 39.6 | 33.0 | 40.1 | 34.6 | 31.2 | 59.6 | 0 | 43.8 | 26.5 | 39.7 |
6.1–12.0 | 14.0 | 23.4 | 21.1 | 16.2 | 13.1 | 16.2 | 13.8 | 0 | 26.1 | 24.0 | 18.0 |
> 12.0 | 5.4 | 20.0 | 34.4 | 22.6 | 9.8 | 40.3 | 9.2 | 0 | 21.0 | 42.2 | 19.7 |
Missingb | 5.7 | 0.2 | 0.3 | 5.3 | 28.9 | 1.2 | 0.5 | 100 | 2.2 | 1.6 | 7.1 |
Age at menarche, years: | |||||||||||
≤ 11 | 17.0 | 23.2 | 18.1 | 19.2 | 10.7 | 9.7 | 10.8 | 6.1 | 8.9 | 8.5 | 14.6 |
12 | 24.6 | 25.0 | 19.6 | 18.1 | 19.9 | 22.5 | 21.9 | 12.0 | 13.6 | 19.8 | 20.7 |
13 | 26.0 | 24.3 | 23.8 | 23.9 | 23.9 | 25.9 | 25.5 | 17.9 | 22.4 | 28.7 | 25.0 |
14 | 20.6 | 17.6 | 22.4 | 19.0 | 21.8 | 20.1 | 23.0 | 15.1 | 25.2 | 24.4 | 21.1 |
≥ 15 | 11.2 | 8.5 | 16.1 | 14.3 | 21.6 | 20.7 | 18.6 | 11.4 | 26.2 | 17.1 | 15.6 |
Missing | 0.6 | 1.4 | 0.0 | 5.5 | 2.1 | 1.1 | 0.2 | 37.5 | 3.7 | 1.5 | 3.0 |
HRT: | |||||||||||
1 (yes) | 31.0 | 17.2 | 11.3 | 31.7 | 22.5 | 5.6 | 38.5 | 14.0 | 43.9 | 31 | 28.0 |
0 (no) | 68.3 | 81.1 | 85.7 | 64.9 | 74.5 | 93.8 | 25.7 | 45.4 | 54.2 | 69 | 66.4 |
Missing | 0.7 | 1.7 | 3.0 | 3.4 | 3.0 | 0.6 | 35.8 | 40.6 | 1.9 | 0 | 5.6 |
Duration of HRT, years: | |||||||||||
≤ 1.0 | 26.4 | 55.2 | 62.0 | 30.0 | 38.0 | 62.0 | 21.6 | 19.2 | 27.9 | 18.3 | 29.2 |
1.1–2.0 | 21.0 | 11.7 | 17.1 | 14.1 | 13.8 | 13.5 | 11.3 | 12.3 | 10.2 | 13.3 | 14.8 |
2.1–3.0 | 14.0 | 8.3 | 6.6 | 10.8 | 9.3 | 5.9 | 10.3 | 7.6 | 8.2 | 10.0 | 10.6 |
> 3.0 | 38.6 | 17.1 | 12.0 | 37.9 | 31.8 | 16.8 | 50.7 | 20.5 | 52.7 | 30.1 | 38.0 |
Missingc | 0.0 | 7.7 | 2.3 | 7.2 | 7.1 | 1.8 | 6.1 | 40.4 | 1.0 | 28.3 | 7.4 |
Height, cm, median | 161 | 158 | 156 | 162 | 164 | 156 | 163 | 164 | 164 | 167 | 162 |
BMI, kg/m2: | |||||||||||
< 25.0 | 77.2 | 46.9 | 21.1 | 58.2 | 50.6 | 20.9 | 47.4 | 57.3 | 51.1 | 64.2 | 56.0 |
2.05–29.9 | 18.5 | 37.5 | 43.7 | 30.3 | 36.4 | 38.4 | 34.6 | 31.5 | 34.6 | 27.7 | 30.4 |
30.0–34.9 | 3.5 | 11.8 | 25.3 | 8.5 | 10.1 | 27.8 | 13.1 | 8.3 | 10.6 | 6.4 | 10.1 |
≥ 35.0 | 0.8 | 3.8 | 9.9 | 3.0 | 2.9 | 12.9 | 4.9 | 2.9 | 3.7 | 1.7 | 3.5 |
Alcohol intake, drinks/day: | |||||||||||
0 | 14.0 | 22.4 | 53.3 | 7.4 | 17.1 | 35.3 | 4.6 | 16.4 | 2.7 | 21.0 | 17.0 |
< 1.0 | 54.4 | 46.6 | 34.2 | 69.5 | 56.4 | 57.2 | 70.8 | 82.9 | 58.2 | 77.5 | 59.8 |
1.0–1.9 | 18.0 | 16.6 | 8.5 | 10.9 | 14.6 | 5.4 | 14.9 | 0.7 | 20.8 | 1.5 | 13.0 |
≥ 2.0 | 13.6 | 13.1 | 4.0 | 6.4 | 11.4 | 1.6 | 9.6 | 0 | 18.2 | 0 | 9.3 |
Missing | 0 | 1.3 | 0 | 5.8 | 0.5 | 0.5 | 0.1 | 0 | 0.1 | 0 | 0.9 |