From: Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts
Risk factors | EPIC study | WHI study | ||
---|---|---|---|---|
ER+, n = 7210 HR (95% CI) | ER-, n = 1598 HR (95% CI) | ER+, n = 2276 HR (95% CI) | ER-, n = 421 HR (95% CI) | |
Menopausal status: | ||||
postmenopausalb vs premenopausal | 0.66 (0.60–0.74) | – | ||
Age at menopause, years: | ||||
45.1–50.0 vs ≤ 45.0 | 1.16 (1.06–1.28) | 1.16 (1.05–1.29) | ||
50.1–55.0 vs ≤ 45.0 | 1.25 (1.13–1.38) | 1.41 (1.27–1.56) | ||
> 55.0 vs ≤ 45.0 | 1.41 (1.21–1.63)e | 1.40 (1.20–1.62) | ||
Breastfeeding, months: | ||||
0.1–6 vs 0 | 1.01 (0.95–1.08) | 1.04 (0.94–1.14) | ||
6.1–12 vs 0 | 0.96 (0.88–1.04) | 1.04 (0.91–1.18) | ||
> 12 vs 0 | 1.01 (0.93–1.11) | 1.07 (0.95–1.20) | ||
Age at menarche, years: | ||||
12 vs ≤ 11 | 1.06 (0.98–1.14) | 0.89 (0.80–0.99) | ||
13 vs ≤ 11 | 1.00 (0.93–1.07) | 0.82 (0.74–0.91) | ||
14 vs ≤ 11 | 0.97 (0.91–1.05) | 0.86 (0.75–0.98) | ||
≥ 15 vs ≤ 11 | 0.85 (0.79–0.92) | 0.78 (0.67–0.91) | ||
HRT use, years: | ||||
0.1–1.0 vs 0 | 1.17 (1.09–1.26) | 1.01 (0.86–1.19) | ||
1.1–2.0 vs 0 | 1.27 (1.15–1.40) | 1.17 (0.97–1.40) | ||
2.1–3.0 vs 0 | 1.39 (1.24–1.56) | 1.37 (1.13–1.65) | ||
> 3.0 vs 0 | 1.55 (1.44–1.66)e | 1.53 (1.39–1.67)e | ||
BMI, kg/m2: | ||||
25.0–29.9 vs < 25.0 | 0.99 (0.92–1.07) | 1.02 (0.93–1.12) | ||
30.0–34.9 vs < 25.0 | 0.97 (0.85–1.10) | 1.14 (1.02–1.28) | ||
≥ 35.0 vs < 25.0 | 1.12 (0.92–1.36) | 1.23 (1.07–1.41) | ||
BMI* menopausec: | ||||
1 vs 0 | 1.11 (1.01–1.23) | – | ||
2 vs 0 | 1.26 (1.07–1.47) | – | ||
3 vs 0 | 1.17 (0.91–1.50) | – | ||
Alcohol intake, drinks per day: | ||||
< 1.0 vs 0 | 1.00 (0.94–1.07) | 1.08 (0.91–1.29) | ||
1.0–1.9 vs 0 | 1.14 (1.05–1.24) | 1.20 (0.98–1.47) | ||
≥ 2.0 vs 0 | 1.22 (1.12–1.33) | 1.26 (1.01–1.59) | ||
FTPd: | ||||
Yes vs no | 0.81 (0.71–0.91) | 0.97 (0.76–1.24) | 0.85 (0.67–1.08) | 0.65 (0.37–1.14) |
Number of FTP: | ||||
2 vs 1 | 0.99 (0.92–1.06) | 1.05 (0.90–1.22) | 1.14 (0.97–1.34) | 1.15 (0.78–1.70) |
≥ 3 vs 1 | 0.87 (0.80–0.95) | 0.95 (0.81–1.13) | 0.99 (0.84–1.17) | 0.96 (0.65–1.41) |
Age at 1st FTP, years: | ||||
20.1–25.0 vs ≤ 20.0 | 1.05 (0.97–1.14) | 1.04 (0.89–1.23) | 1.03 (0.89–1.20) | 1.37 (0.97–1.95) |
25.1–30.0 vs ≤ 20.0 | 1.20 (1.10–1.31) | 0.93 (0.78–1.12) | 1.14 (0.97–1.33) | 1.34 (0.92–1.96) |
30.1–35.0 vs ≤ 20.0 | 1.32 (1.18–1.48) | 0.96 (0.75–1.23) | 1.59 (1.31–1.94) | 1.01 (0.58–1.75) |
> 3.05 vs ≤ 20.0 | 1.46 (1.24–1.73)e | 0.91 (0.59–1.38) | 1.56 (1.16–2.09) | 1.10 (0.48–2.53) |
Height, per 10-cm increment | 1.19 (1.15–1.24) | 1.06 (0.98–1.16) | 1.14 (1.06–1.22) | 1.04 (0.89–1.22) |