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Table 1 Genome-wide expression studies of LNs of breast carcinoma patients

From: Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients

Clinical question Study Breast carcinoma Sample cohort Results
Scenario 1
Involved lymph node (ILN) versus primary tumours (PT)
Calvo et al. [36], 2013 IDC 18 PT vs matching ILN Infrequent loss of luminal differentiation in metastatic LN
Feng et al. [37], 2007 IDC 26 PT vs matching ILN 79 DEG
Hao et al. & Lähdesmäki et al. [38, 39], 2004 Invasive BC 9 PT vs matching ILN 280 DEG
Weigelt et al [40], 2005 Invasive BC 15 PT vs matching ILN No classifier or single gene could discriminate
Ellsworth et al. [41], 2009 Invasive BC 20 PT vs matching ILN 51 DEG
Vecchi et al. [42], 2008 Invasive BC 26 PT vs matching ILN 270 DEG
Suzuki et al. [43], 2007 Invasive BC 10 PT vs matching ILN 84 DEG
Scenario 2
Involved LN versus normal adjacent breast tissue (NAT)
Mathe et al. [44], 2015 TNBC 15 ILN vs 17 NAT 83 genes were significantly associated with LN metastasis
Scenario 3
Uninvolved LN in LN-positive versus LN-negative patients
Zuckerman et al. [45], 2013 Invasive BC 11 PT, 30 LN, 21 PB 116/219 DEG (SLN/NSLN, respectively)
Blackburn et al. [46], 2017 Invasive BC 24 LN from NP vs 40 LN from NN No genes were differentially expressed with stringent FDR
Scenario 4
Uninvolved residual portion of involved LN versus uninvolved LN
Valente et al. [47], 2014 Invasive BC 20 matched pairs of involved and uninvolved LN 22 DEG
Zuckerman et al. [45], 2013 Invasive BC 11 PT, 30 LN, 21 PB 103 DEG
Scenario 5
Involved LN versus uninvolved LN
Rizwan et al. [48], 2015 Invasive BC 16 involved vs 3 uninvolved LN 13 DEG
Scenario 6
Positive sentinel LNs in patients with additional, non-sentinel, positive LNs to patients with additional, non-sentinel, negative LNs
Liang et al. [49], 2015 Invasive BC 3 NSLN+ SLN vs 3 NSLN− SLN 160 DEG
  1. BC breast carcinoma, DEG differentially expressed genes, IDC invasive ductal carcinoma (no special type), ILN involved LN, LN lymph node, NAT normal adjacent breast tissue, NN node-negative patients, NP node-positive patients, NSLN non-sentinel lymph node, PT primary tumour, SLN sentinel lymph node