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Table 1 Genome-wide expression studies of LNs of breast carcinoma patients

From: Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients

Clinical question

Study

Breast carcinoma

Sample cohort

Results

Scenario 1

Involved lymph node (ILN) versus primary tumours (PT)

Calvo et al. [36], 2013

IDC

18 PT vs matching ILN

Infrequent loss of luminal differentiation in metastatic LN

Feng et al. [37], 2007

IDC

26 PT vs matching ILN

79 DEG

Hao et al. & Lähdesmäki et al. [38, 39], 2004

Invasive BC

9 PT vs matching ILN

280 DEG

Weigelt et al [40], 2005

Invasive BC

15 PT vs matching ILN

No classifier or single gene could discriminate

Ellsworth et al. [41], 2009

Invasive BC

20 PT vs matching ILN

51 DEG

Vecchi et al. [42], 2008

Invasive BC

26 PT vs matching ILN

270 DEG

Suzuki et al. [43], 2007

Invasive BC

10 PT vs matching ILN

84 DEG

Scenario 2

Involved LN versus normal adjacent breast tissue (NAT)

Mathe et al. [44], 2015

TNBC

15 ILN vs 17 NAT

83 genes were significantly associated with LN metastasis

Scenario 3

Uninvolved LN in LN-positive versus LN-negative patients

Zuckerman et al. [45], 2013

Invasive BC

11 PT, 30 LN, 21 PB

116/219 DEG (SLN/NSLN, respectively)

Blackburn et al. [46], 2017

Invasive BC

24 LN from NP vs 40 LN from NN

No genes were differentially expressed with stringent FDR

Scenario 4

Uninvolved residual portion of involved LN versus uninvolved LN

Valente et al. [47], 2014

Invasive BC

20 matched pairs of involved and uninvolved LN

22 DEG

Zuckerman et al. [45], 2013

Invasive BC

11 PT, 30 LN, 21 PB

103 DEG

Scenario 5

Involved LN versus uninvolved LN

Rizwan et al. [48], 2015

Invasive BC

16 involved vs 3 uninvolved LN

13 DEG

Scenario 6

Positive sentinel LNs in patients with additional, non-sentinel, positive LNs to patients with additional, non-sentinel, negative LNs

Liang et al. [49], 2015

Invasive BC

3 NSLN+ SLN vs 3 NSLN− SLN

160 DEG

  1. BC breast carcinoma, DEG differentially expressed genes, IDC invasive ductal carcinoma (no special type), ILN involved LN, LN lymph node, NAT normal adjacent breast tissue, NN node-negative patients, NP node-positive patients, NSLN non-sentinel lymph node, PT primary tumour, SLN sentinel lymph node