From: Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients
Clinical question | Study | Breast carcinoma | Sample cohort | Results |
---|---|---|---|---|
Scenario 1 Involved lymph node (ILN) versus primary tumours (PT) | Calvo et al. [36], 2013 | IDC | 18 PT vs matching ILN | Infrequent loss of luminal differentiation in metastatic LN |
Feng et al. [37], 2007 | IDC | 26 PT vs matching ILN | 79 DEG | |
Invasive BC | 9 PT vs matching ILN | 280 DEG | ||
Weigelt et al [40], 2005 | Invasive BC | 15 PT vs matching ILN | No classifier or single gene could discriminate | |
Ellsworth et al. [41], 2009 | Invasive BC | 20 PT vs matching ILN | 51 DEG | |
Vecchi et al. [42], 2008 | Invasive BC | 26 PT vs matching ILN | 270 DEG | |
Suzuki et al. [43], 2007 | Invasive BC | 10 PT vs matching ILN | 84 DEG | |
Scenario 2 Involved LN versus normal adjacent breast tissue (NAT) | Mathe et al. [44], 2015 | TNBC | 15 ILN vs 17 NAT | 83 genes were significantly associated with LN metastasis |
Scenario 3 Uninvolved LN in LN-positive versus LN-negative patients | Zuckerman et al. [45], 2013 | Invasive BC | 11 PT, 30 LN, 21 PB | 116/219 DEG (SLN/NSLN, respectively) |
Blackburn et al. [46], 2017 | Invasive BC | 24 LN from NP vs 40 LN from NN | No genes were differentially expressed with stringent FDR | |
Scenario 4 Uninvolved residual portion of involved LN versus uninvolved LN | Valente et al. [47], 2014 | Invasive BC | 20 matched pairs of involved and uninvolved LN | 22 DEG |
Zuckerman et al. [45], 2013 | Invasive BC | 11 PT, 30 LN, 21 PB | 103 DEG | |
Scenario 5 Involved LN versus uninvolved LN | Rizwan et al. [48], 2015 | Invasive BC | 16 involved vs 3 uninvolved LN | 13 DEG |
Scenario 6 Positive sentinel LNs in patients with additional, non-sentinel, positive LNs to patients with additional, non-sentinel, negative LNs | Liang et al. [49], 2015 | Invasive BC | 3 NSLN+ SLN vs 3 NSLN− SLN | 160 DEG |