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Table 5 Complete blood counts in patients with circulating tumor cell clusters

From: Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

  No CTC clusters (n = 61) CTC clusters (n = 12) P value Estimate (95% CI)
CA 15-3, mean (SD) 172.5 (324.45) 2554.6 (6387.64) 0.021 204.16 (9.7–515)
Alkaline phosphatase, mean (SD) 106.4 (104.27) 310.25 (525.57) 0.301 10 (− 12, 74.58)
Calcium (korr), mean (SD) 2.33 (0.14) 2.36 (0.35) 0.698 − 0.02 (− 0.16, 0.14)
CRP, mean (SD) 27.76 (44.47) 37.25 (58.6) 0.279 2.9 (− 4, 21.4)
LDH, mean (SD) 271 (102.59) 363.33 (329.24) 0.463 17 (− 26, 76)
RBC, 1012/L, mean (SD) 4.26 (0.6) 3.66 (0.93) 0.078 − 0.51 (− 1.16, 0.06)
HGB, g/L, mean (SD) 127.52 (20.18) 114.18 (29.19) 0.183 − 12 (− 30, 6)
HCT, L/L, mean (SD) 0.38 (0.05) 0.34 (0.08) 0.159 − 0.03 (− 0.09, 0.01)
MCV, fl, mean (SD) 87.7 (5.58) 91.73 (4.41) 0.033 4 (0–7)
MCH, pg, mean (SD) 29.8 (2.42) 31.24 (1.51) 0.064 1.1 (0–2.3)
MCHC, g/L, mean (SD) 339.8 (13.38) 340.64 (14.25) 0.646 2 (− 10, 10)
WBC, 109/L, mean (SD) 6.87 (2.25) 9.38 (3.99) 0.030 2.54 (0.26–4.68)
Neutrophils, 109/L, mean (SD) 4.94 (1.87) 6.65 (3.6) 0.177 1.22 (− 0.52, 3.68)
Lymphocytes, 109/L, mean (SD) 1.38 (0.69) 1.42 (1) 0.756 − 0.11 (− 0.62, 0.6)
Monocytes, 109/L, mean (SD) 0.41 (0.13) 0.5 (0.24) 0.336 0.06 (− 0.08, 0.26)
Eosinophils, 109/L, mean (SD) 0.16 (0.16) 0.17 (0.14) 0.974 0 (− 0.07, 0.1)
Basophils, 109/L, mean (SD) 0.04 (0.06) 0.04 (0.04) 0.983 0 (− 0.02, 0.02)
LUC, 109/L, mean (SD) 0.14 (0.19) 0.12 (0.11) 0.471 − 0.01 (− 0.05, 0.02)
PLT, 109/L, mean (SD) 278.02 (125.8) 251.5 (109.99) 0.667 − 15.84 (− 94, 47)
MPV, fl, mean (SD) 8.32 (1.62) 8.82 (0.87) 0.032 1 (0–1)
  1. Abbreviations: CA 15-3 Cancer antigen 15-3, CRP C-reactive protein, HCT Hematocrit, HGB Hemoglobin, LDH Lactate dehydrogenase, LUC Large unstained cells, MCH Mean corpuscular hemoglobin, MCHC Mean corpuscular hemoglobin concentration, MCV Mean corpuscular volume, MPV Mean platelet volume, PLT Platelets, RBC Red blood cells, WBC White blood cells
  2. The table shows complete blood counts in patients with and without circulating tumor cell clusters (CTC clusters)