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Table 3 Association between the general cognitive factor and inflammatory markers in breast cancer survivors and in non-exposed participants

From: Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study

Inflammatory marker per SD increase

Breast cancer survivors

Non-exposed participants

P for interaction†

Mean difference* (95% CI)

Mean difference* (95% CI)

Model I

 Log GLR

−0.24 (−0.40 to −0.08)

−0.04 (−0.09 to 0.00)

0.061

 Log PLR

−0.13 (−0.29 to 0.03)

0.05 (0.01 to 0.10)

0.003

 Log SII

−0.22 (−0.38 to −0.07)

−0.03 (−0.08 to 0.01)

0.053

Model II

 Log GLR

−0.23 (−0.39 to −0.08)

−0.02 (−0.07 to 0.02)

0.038

 Log PLR

−0.18 (−0.33 to −0.02)

0.03 (−0.01 to 0.08)

0.003

 Log SII

−0.23 (−0.38 to −0.07)

−0.01 (−0.06 to 0.03)

0.033

  1. Abbreviations: CI confidence interval, GLR granulocyte-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SD standard deviation, SII systemic immune-inflammation index
  2. Model I is a linear regression of the general cognitive factor on each log-transformed inflammatory marker adjusted for age and education. Model II is as model I plus adjustment for smoking status, body mass index, diabetes mellitus, history of stroke, history of myocardial infarction, and Center for Epidemiologic Studies Depression Scale (CES-D) sum-score
  3. *Mean difference in general cognitive factor per standard deviation increase in inflammatory marker
  4. †P value for interaction term between history of cancer/cancer treatment and inflammatory marker