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Table 3 Risk of incident osteopenia and osteoporosis among breast cancer survivors compared with cancer-free women, stratified by characteristics at diagnosis

From: Evaluation of osteopenia and osteoporosis in younger breast cancer survivors compared with cancer-free women: a prospective cohort study

 

Events/person-years

Age-adjusted HR (95% CI)

MV-adjusted HRa (95% CI)a

Age at diagnosis

 Cancer-free

67/3509

1.00 (reference)

1.00 (reference)

  ≤ 50 years

27/651

2.34 (1.46–3.75)

1.98 (1.21–3.24)

  > 50 years

18/375

1.64 (0.93–2.88)

1.34 (0.75–2.40)

Menopausal status at diagnosis

 Cancer-free

67/3509

1.00 (reference)

1.00 (reference)

 Premenopausal at diagnosis

27/728

1.97 (1.24–3.12)

1.76 (1.09–2.84)

 Postmenopausal at diagnosis

18/298

2.05 (1.15–3.64)

1.58 (0.86–2.89)

ER statusb

 Cancer-free

67/3509

1.00 (reference)

1.00 (reference)

 ER-negative

7/200

1.68 (0.76–3.72)

1.26 (0.54–2.94)

 ER-positive

32/611

2.32 (1.52–3.55)

2.10 (1.34–3.29)

  1. Abbreviations: ER Estrogen receptor, MV Multivariable
  2. aAdjusted for age (years), menopausal status (premenopausal, postmenopausal), bilateral oophorectomy at age < 45 years (yes, no), body mass index (kg/m2), physical activity (MET-h/wk), smoking status (never, ever), alcohol intake (g/d), and hormone replacement therapy (never, ever)
  3. bBreast cancer survivors were restricted to stages I–III