Skip to main content

Table 2 Risk of incident osteopenia and osteoporosis among breast cancer survivors compared with cancer-free women

From: Evaluation of osteopenia and osteoporosis in younger breast cancer survivors compared with cancer-free women: a prospective cohort study

  Events/person-years Age-adjusted HR (95% CI) MV-adjusted HR (95% CI)a
Overall
 Cancer-free 67/3509 1.00 (reference) 1.00 (reference)
 Breast cancer survivors 45/1026 2.01 (1.38–2.94) 1.68 (1.12–2.50)
Excluding women without bone density examinations prior to baseline
 Cancer-free 27/1023 1.00 (reference) 1.00 (reference)
 Breast cancer survivors 27/497 1.96 (1.15–3.36) 1.90 (1.08–3.34)
Excluding women without bone density examinations during follow-up
 Cancer-free 63/1890 1.00 (reference) 1.00 (reference)
 Breast cancer survivors 45/703 1.89 (1.29–2.78) 1.72 (1.14–2.58)
Excluding early bilateral oophorectomy prior to baselineb
 Cancer-free 64/3347 1.00 (reference) 1.00 (reference)
 Breast cancer survivors 42/957 1.93 (1.30–2.85) 1.63 (1.08–2.46)
Excluding pre- to postmenopausal during follow-up
 Cancer-free 34/2308 1.00 (reference) 1.00 (reference)
 Breast cancer survivors 32/745 2.18 (1.34–3.55) 1.57 (0.93–2.63)
Excluding current vitamin D usersc
 Cancer-free 60/3263 1.00 (reference) 1.00 (reference)
 Breast cancer survivors 36/820 2.03 (1.34–3.08) 1.68 (1.08–2.61)
Excluding current calcium usersc
 Cancer-free 40/2637 1.00 (reference) 1.00 (reference)
 Breast cancer survivors 28/743 2.14 (1.32–3.48) 1.59 (0.95–2.68)
  1. Abbreviations: MV Multivariable
  2. aAdjusted for age (years), menopausal status (premenopausal, postmenopausal), bilateral oophorectomy at age < 45 years (yes, no), body mass index (kg/m2), physical activity (MET-h/wk), smoking status (never, ever), alcohol intake (g/d), and hormone replacement therapy (never, ever)
  3. bBoth ovaries removed prior to age 45 years
  4. cVitamin D and calcium supplement use was ascertained at baseline