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Table 3 Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) from Cox proportional hazards modelling of body mass index, menopausal status, age, and BOADICEA 1-year risk of breast cancer at baseline

From: Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC)

Model

 

HRb

95% CI

P

ΔLLc

V

Log body mass indexa (per 5 kg/m2)

0.75

0.46, 1.22

0.2

158.03

Log 1-year BOADICEAa (%)

2.05

1.89, 2.23

< 0.001

Age at baseline, years

0.98

0.96, 1.00

0.1

Menopause, no/yes

1.04

0.81, 1.32

0.8

Log body mass index (per 5 kg/m2) × Menopause, no/yes

3.36

1.71, 6.62

< 0.001

VI

Log body mass indexa (per 5 kg/m2)

0.75

0.46, 1.22

0.2

158.03

Log 1-year BOADICEAa (%)

2.05

1.86, 2.26

< 0.001

Age at baseline, years

0.98

0.96, 1.00

0.1

Menopause, no/yes

1.03

0.80, 1.34

0.8

Log body mass index (per 5 kg/m2) × Menopause, no/yes

3.36

1.71, 6.63

< 0.001

Menopause, no/yes × Log 1-year BOADICEAa (%)

1.00

0.85, 1.19

1.0

VII

Log body mass indexa (per 5 kg/m2)

0.70

0.41, 1.18

0.2

158.24

Log 1-year BOADICEAa (%)

2.06

0.89, 2.24

< 0.001

Age at baseline, years

0.98

0.96, 1.00

0.1

Menopause, no/yes

1.04

0.81, 1.32

0.8

Log body mass index (per 5 kg/m2) × Menopause, no/yes

3.46

1.75, 6.84

< 0.001

Log body mass indexa (per 5 kg/m2) × log 1-year BOADICEAa (%)

1.13

0.79, 1.62

0.5

VIII

Log body mass indexa (per 5 kg/m2)

0.66

0.38, 1.14

0.1

158.54

Log 1-year BOADICEAa (%)

2.07

1.90, 2.25

< 0.001

Age at baseline, years

0.98

0.96, 1.00

0.1

Menopause, no/yes

1.04

0.82, 1.32

0.8

Log body mass index (per 5 kg/m2) × Menopause, no/yes

3.92

1.86, 8.28

< 0.001

Log body mass indexa (per 5 kg/m2) × Log 1-year BOADICEAa (%)

1.27

0.81, 2.00

0.3

Menopause, no/yes × Log body mass indexa (per 5 kg/m2) × Log 1-year BOADICEAa (%)

0.73

0.34, 1.57

0.4

  1. To account for clustering by family, robust 95% CIs are reported
  2. LL log likelihood, BOADICEA Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm
  3. aAdjusted for log baseline age as a quadratic
  4. bAdjusted for history of benign breast disease, race/ethnicity, and education; stratified by year of birth (10-year groups) and study site
  5. cChange in LL from the base model that includes history of benign breast disease, race/ethnicity, and education