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Table 3 Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) from Cox proportional hazards modelling of body mass index, menopausal status, age, and BOADICEA 1-year risk of breast cancer at baseline

From: Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC)

Model   HRb 95% CI P ΔLLc
V Log body mass indexa (per 5 kg/m2) 0.75 0.46, 1.22 0.2 158.03
Log 1-year BOADICEAa (%) 2.05 1.89, 2.23 < 0.001
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.04 0.81, 1.32 0.8
Log body mass index (per 5 kg/m2) × Menopause, no/yes 3.36 1.71, 6.62 < 0.001
VI Log body mass indexa (per 5 kg/m2) 0.75 0.46, 1.22 0.2 158.03
Log 1-year BOADICEAa (%) 2.05 1.86, 2.26 < 0.001
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.03 0.80, 1.34 0.8
Log body mass index (per 5 kg/m2) × Menopause, no/yes 3.36 1.71, 6.63 < 0.001
Menopause, no/yes × Log 1-year BOADICEAa (%) 1.00 0.85, 1.19 1.0
VII Log body mass indexa (per 5 kg/m2) 0.70 0.41, 1.18 0.2 158.24
Log 1-year BOADICEAa (%) 2.06 0.89, 2.24 < 0.001
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.04 0.81, 1.32 0.8
Log body mass index (per 5 kg/m2) × Menopause, no/yes 3.46 1.75, 6.84 < 0.001
Log body mass indexa (per 5 kg/m2) × log 1-year BOADICEAa (%) 1.13 0.79, 1.62 0.5
VIII Log body mass indexa (per 5 kg/m2) 0.66 0.38, 1.14 0.1 158.54
Log 1-year BOADICEAa (%) 2.07 1.90, 2.25 < 0.001
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.04 0.82, 1.32 0.8
Log body mass index (per 5 kg/m2) × Menopause, no/yes 3.92 1.86, 8.28 < 0.001
Log body mass indexa (per 5 kg/m2) × Log 1-year BOADICEAa (%) 1.27 0.81, 2.00 0.3
Menopause, no/yes × Log body mass indexa (per 5 kg/m2) × Log 1-year BOADICEAa (%) 0.73 0.34, 1.57 0.4
  1. To account for clustering by family, robust 95% CIs are reported
  2. LL log likelihood, BOADICEA Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm
  3. aAdjusted for log baseline age as a quadratic
  4. bAdjusted for history of benign breast disease, race/ethnicity, and education; stratified by year of birth (10-year groups) and study site
  5. cChange in LL from the base model that includes history of benign breast disease, race/ethnicity, and education