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Table 2 Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) from Cox proportional hazards modeling of body mass index, menopausal status and age at baseline

From: Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC)

Model   HRb 95% CI P ΔLLc
I Log body mass indexa (per 5 kg/m2) 1.28 0.91, 1.81 0.2 2.38
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.12 0.88, 1.43 0.4
II Log body mass indexa (per 5 kg/m2) 0.13 0.03, 0.56 0.006 7.36
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.12 0.88, 1.44 0.4
Log body mass index (per 5 kg/m2) × Age at baseline, years 1.05 1.02, 1.08 0.002
III Log body mass indexa (per 5 kg/m2) 0.68 0.41, 1.01 0.1 9.14
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.12 0.87, 1.44 0.4
Log body mass index (per 5 kg/m2) × Menopause, no/yes 3.68 1.86, 7.28 < 0.001
IV Log body mass indexa (per 5 kg/m2) 0.40 0.06, 2.89 0.4 9.32
Age at baseline, years 0.98 0.96, 1.00 0.1
Menopause, no/yes 1.12 0.88, 1.44 0.4
Log body mass index (per 5 kg/m2) × Age at baseline, years 1.01 0.97, 1.06 0.6
Log body mass index (per 5 kg/m2) × Menopause, no/yes 2.91 0.91, 9.31 0.07
  1. To account for clustering by family, robust 95% CIs are reported
  2. LL log likelihood
  3. aAdjusted for log baseline age as a quadratic
  4. bAdjusted for history of benign breast disease, race/ethnicity, and education; stratified by year of birth (10-year groups) and study site
  5. cChange in LL from the base model that includes benign breast disease, race/ethnicity, and education