Skip to main content

Advertisement

Table 1 Baseline characteristics of study cohort and unadjusted hazard ratios (HRs) and 95% confidence intervals (CIs) from Cox proportional hazards analysis

From: Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC)

  Unaffected Affected HR 95% CI P
Number Percentage Number Percentage
Age at baseline, years
 18–29 2407 15.9 49 5.5 1.00 (referent)  
 30–39 3087 20.4 182 20.3 1.34 0.81, 2.20 0.3
 40–49 3189 21.1 231 25.8 1.18 0.65, 2.14 0.6
 50–59 2869 19.0 232 25.9 1.20 0.60, 2.40 0.6
 60–69 2179 14.4 166 18.5 0.98 0.46, 2.11 1.0
 70–79 1408 9.3 36 4.0 0.53 0.20, 1.38 0.2
1-year BOADICEA, %
 Q1: 0–0.13 4010 26.5 84 9.4 1.00 (referent)  
 Q2: 0.14–0.34 3167 23.9 188 21.0 2.14 1.51, 3.04 < 0.001
 Q3: 0.35–0.53 3672 24.3 241 26.9 3.41 2.38, 4.89 < 0.001
 Q4: 0.54–7.94 3840 25.4 383 42.8 5.20 3.65, 7.42 < 0.001
Body mass index, kg/m2
 Q1: 14.69–21.86 3811 25.2 194 21.7 1.00 (referent)  
 Q2: 21.87–24.60 3766 24.9 227 25.3 1.07 0.89, 1.30 0.5
 Q3: 24.61–28.56 3771 24.9 252 28.1 1.17 0.96, 1.41 0.1
 Q4: 28.57–58.86 3791 25.0 223 24.9 1.05 0.87, 1.28 0.6
History of benign breast disease
 No 10,953 72.4 551 61.5 1.00 (referent)  
 Yes 3878 25.6 323 36.1 1.33 1.15, 1.54 < 0.001
Menopausal status
 Premenopausal 8669 57.3 467 52.1 1.00 (referent)  
 Postmenopausal 6470 42.7 429 47.9 1.02 0.81, 1.29 0.8
Race/ethnicity
 Non-Hispanic white 11,969 79.1 750 83.7 1.00 (referent)  
 Black 726 4.8 29 3.2 0.60 0.40, 0.89 0.01
 Hispanic 1310 8.7 52 5.8 0.74 0.53, 1.04 0.08
 Asian 574 3.8 39 4.4 0.87 0.60, 1.26 0.5
 Other 417 2.8 17 1.9 0.72 0.45, 1.15 0.2
 Missing 143 0.9 9 1.0    
Education, highest completed
 High school or general education development 5031 33.2 260 29.0 1.00 (referent)  
 Vocational, technical, or some college or university 5709 37.7 319 35.6 1.15 0.97, 1.37 0.1
 Bachelor or graduate degree 4341 28.7 313 34.9 1.42 1.18, 1.70 < 0.001
 Missing 58 0.4 4 0.5    
  1. HRs are unadjusted but stratified by birth cohort (10-year groups) and study site; to account for clustering by family, robust 95% CIs are reported
  2. Q1–Q4 quartiles 1–4