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Fig. 2 | Breast Cancer Research

Fig. 2

From: Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

Fig. 2

Differences in protective immunity induced by irradiated breast cancer cell lines. Balb/cByJ mice (n = 8 per group) received 1 × 106 irradiated 4T1 cells (4T1 vaccine) or 5 × 105 irradiated EMT6 cells (EMT6 vaccine) twice, 10 days apart. Ten days after the booster vaccination, mice were challenged with live 5 × 105 4T1 or EMT6 cells, respectively. Additionally, naive mice that received only 5 × 105 live EMT6 cells (EMT6 control) or live 4T1 cells (4T1 control) served as controls for each group. Tumor volumes (a) and tumor-free survival (b) were recorded. (*p < 0.05 vs. naïve/4T1 challenge group, **p < 0.01 vs. naïve/EMT6 challenge group, log rank test)

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