Skip to main content

Table 2 Comparison of bone health between exercise and usual care groups

From: Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial

  Baseline Post-intervention 3-month follow-up Between-group difference post-intervention
Mean (SD) Mean (SD) P valuea Mean (SD) P valueb Mean (95% CI) P valuec
Calcium (mg/dL)
 Exercise 10.3 (2.6) 13.7 (1.9) 0.09 13.4 (1.7) 0.10 3.4 (5.0 to 1.6) 0.10
 Usual care 10.5 (2.5) 9.9 (2.6) 0.67
25(OH)D (ng/dL)
 Exercise 21.7 (4.4) 27.8 (6.7) 0.09 27.4 (6.5) 0.09 6.1 (9.8 to 4.3) 0.10
 Usual care 21.5 (4.1) 20.9 (4.0) 0.57
Osteocalcin (ng/mL)
 Exercise 12.1 (3.1) 15.0 (4.1) 0.01 14.7 (3.5) 0.01 3.1 (5.6 to 1.5) 0.01
 Usual care 12.3 (3.4) 12.0 (3.0) 0.61
BSAP (ng/mL)
 Exercise 16.1 (4.6) 18.0 (5.0) 0.01 17.7 (4.6) 0.01 1.9 (2.4 to 0.55) 0.001
 Usual care 16.2 (4.3) 15.9 (4.2) 0.55
CTX (ng/mL)
 Exercise 0.48 (0.1) 0.44 (0.2) 0.07 0.44 (0.2) 0.07 −0.04 (−0.10 to −0.06) 0.10
 Usual care 0.47 (0.1) 0.48 (0.2) 0.74
NTX (nM BCE/L)
 Exercise 18.6 (3.1) 17.7 (2.8) 0.10 17.8 (2.7) 0.11 −0.90 (−1.1 to − 0.6) 0.12
 Usual care 18.4 (2.7) 18.3 (2.5) 0.67
RANK (pg/mL)
 Exercise 27.4 (6.8) 26.7 (6.4) 0.14 26.6 (6.1) 0.14 −0.70 (−0.9 to − 0.4) 0.20
 Usual care 26.9 (6.6) 26.4 (6.5) 0.34
RANKL (pmol/L)
 Exercise 142.5 (18.9) 146.1 (16.1) 0.09 145.7 (16.2) 0.09 3.6 (5.1 to 1.2) 0.14
 Usual care 139.8 (18.1) 148.8 (18.9) 0.47
Whole body BMD (g/cm2)
 Exercise 1.22 (0.1) 1.27 (0.1) 0.15 1.26 (0.1) 0.16 0.05 (0.04 to 0.02) 0.15
 Usual care 1.20 (0.1) 1.19 (0.1) 0.29
Lumbar spine BMD (g/cm2)
 Exercise 1.16 (0.09) 1.20 (0.09) 0.09 1.20 (0.1) 0.09 0.04 (0.03 to 0.01) 0.10
 Usual care 1.15 (0.09) 1.14 (0.09) 0.57
Total hip BMD (g/cm2)
 Exercise 0.91 (0.09) 0.94 (0.09) 0.17 0.94 (0.09) 0.17 0.03 (0.03 to 0.00) 0.18
 Usual care 0.90 (0.09) 0.89 (0.08) 0.23
Trochanter BMD (g/cm2)
 Exercise 0.72 (0.07) 0.74 (0.07) 0.18 0.74 (0.07) 0.20 0.02 (0.03 to 0.00) 0.22
 Usual care 0.71 (0.06) 0.70 (0.06) 0.43
Femoral neck BMD (g/cm2)
 Exercise 0.88 (0.1) 0.90 (0.1) 0.21 0.88 (0.7) 0.24 0.02 (0.03 to 0.00) 0.21
 Usual care 0.87 (0.1) 0.86 (0.1) 0.23
  1. Abbreviations: SD standard deviation, CI confidence interval, BMD bone mineral density, RANK receptor activator factor-kappa B, RANKL receptor activator factor-kappa B ligand
  2. aP value for repeated measures ANOVA comparing changes in the exercise group from baseline to post-intervention, and in the usual care group from baseline to post-intervention
  3. bP value for repeated measures ANOVA comparing changes in the exercise group from baseline to 3-month follow-up
  4. cP value for mixed model analysis comparing changes between the exercise and usual care group from baseline to post-intervention