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Table 3 Associationa between road traffic noise Lden and incidence of breast cancer by ER and PR status in 22,466 nurses with estrogen and progesterone hormone receptor status from the Danish Nurse Cohort

From: Long-term exposure to road traffic noise and incidence of breast cancer: a cohort study

  Breast cancer type by ER status Breast cancer type by PR status
Number of cases ER+ Number of cases ER- Number of cases PR+ Number of cases PR-
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
24 years preceding diagnosis
 Linear per 10 dB 494 1.23 (1.06–1.43)* 117 0.93 (0.70–1.25) 393 1.21 (1.02–1.42)* 218 1.10 (0.89–1.37)
 Low < 48 dB 58 1.00 22 1.00 45 1.00 35 1.00
 Medium 48–58 dB 290 1.48 (1.10–1.98)* 62 0.77 (0.46–1.28) 231 1.51 (1.08–2.10)* 121 0.99 (0.67–1.47)
 High > 58 dB 146 1.59 (1.14–2.20)* 33 0.97 (0.54–1.75) 117 1.66 (1.14–2.40)* 62 1.11 (0.70–1.75)
10 years preceding diagnosis
 Linear per 10 dB 494 1.22 (1.07–1.40)* 117 1.00 (0.76–1.30) 393 1.20 (1.03–1.40)* 218 1.13 (0.92–1.37)
 Low < 48 dB 64 1.00 23 1.00 51 1.00 36 1.00
 Medium 48–58 dB 279 1.55 (1.17–2.05)* 64 0.90 (0.54–1.48) 223 1.55 (1.13–2.12)* 120 1.13 (0.77–1.67)
 High > 58 dB 151 1.65 (1.20–2.26)* 30 0.89 (0.49–1.61) 119 1.65 (1.16–2.35)* 62 1.16 (0.74–1.81)
1 year at the year of diagnosis
 Linear per 10 dB 494 1.18 (1.04–1.33)* 116 1.10 (0.85–1.42) 392 1.21 (1.05–1.39)* 218 1.08 (0.90–1.31)
 Low < 48 dB 77 1.00 21 1.00 59 1.00 39 1.00
 Medium 48–58 dB 268 1.34 (1.03–1.74)* 65 1.13 (0.68–1.89) 216 1.42 (1.05–1.91)* 117 1.11 (0.76–1.62)
 High > 58 dB 149 1.47 (1.09–1.98)* 30 1.12 (0.61–2.03) 117 1.53 (1.09–2.15)* 62 1.18 (0.76–1.82)
  1. Abbreviations: ER Estrogen receptor, PR Progesterone receptor
  2. aModel adjusted for birth cohort, urbanization (urban, provincial, rural), body mass index (underweight, normal, overweight, obese), leisure time physical activity (low, medium, high), alcohol consumption (low, moderate, heavy), age at menarche (≤ 12 years of age, > 12 years of age), parity (nulliparous, parous), number of births, age at first birth, menopausal status (premenopausal, postmenopausal), use of hormone therapy (never, past, current), use of oral contraceptives (never, ever) and smoking status
  3. *p value <0.05