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Fig. 7 | Breast Cancer Research

Fig. 7

From: Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro

Fig. 7

Biodistribution and antitumor activity of nanoparticle-paclitaxel–small interfering RNA (NP-TAX–siRNA). a Ex vivo fluorescence imaging of major organs from MCF-7 tumor-bearing mice 10 h after intravenous injection with saline or Cy5.5-labeled NP-TAX–siRNA. b Mice bearing tumors were injected intravenously with different reagents (PBS, Blank NPs, Free siRNA, Free TAX, SP-siRNA, NP-TAX, and NP-TAX–siRNA) every other day from day 3 for a total of six injections. NP-TAX–siRNA treatment dramatically inhibited tumor growth compared with the control groups. Statistical analyses were performed by using a Kruskal–Wallis test followed by the Mann–Whitney test. *P <0.05 (n = 5–6). c Immunohistochemical staining of metadherin (MTDH) protein in tumor tissue in various treatment groups. Abbreviation: PBS phosphate-buffered saline

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Breast Cancer Research

ISSN: 1465-542X

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