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Fig. 4 | Breast Cancer Research

Fig. 4

From: Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro

Fig. 4

Effect of metadherin (MTDH) overexpression on MCF-7 tumorigenicity and paclitaxel (TAX) resistance. a and b In vivo imaging system was used to analyze the growth of xenograft tumors in the untreated group (a) and the TAX treatment group (b). c Without TAX treatment, the tumor volume was larger in the MCF-7–MTDH group compared with the MCF-7 control group. d In the TAX-treated group, the tumor volumes of the MCF-7–MTDH-short hairpin RNA (MCF-7–MTDH–shRNA) group were significantly smaller than those of the control group. e and f The tumor weights in both MCF-7–MTDH and MCF-7–MTDH–shRNA show consistent trends with tumor volume. *P <0.05, **P <0.01, and ***P <0.001 compared with MCF-7

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Breast Cancer Research

ISSN: 1465-542X

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