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Fig. 6 | Breast Cancer Research

Fig. 6

From: Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

Fig. 6

Proposed working model for role of sterol regulatory element-binding protein 1 (SREBP1) signaling in invasive lobular carcinoma (ILC) long-term estrogen deprivation (LTED) cells. Genes: the upregulated genes in MM134 or SUM44 LTED cells compared with parental cells, which were validated in the in vitro experiments or based on the RNA-sequencing (RNA-Seq) data or both. Black arrow, the potential pathway of SREBP1 promoting the survival of LTED cells

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