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Table 3 Statistical analysis of TransATAC validation cohort

From: Novel 18-gene signature for predicting relapse in ER-positive, HER2-negative breast cancer

Score No. of patients (relapses) Univariate comparisons Multivariable comparisons
CTS + signature vs CTS CTS + signature
LRχ2 p Value HR (95% CI) P diff C-index (SE) ΔLRχ2 p Value HR (95% CI) P diff C-index (SE)
0–10 years  
 CTS 314 (59) 48.7 < 0.001 2.16 (1.79–2.62) 0.674 (0.018)
 10-Year signature 28 < 0.001 1.98 (1.54–2.55) Reference 0.671 (0.026) 7.9 0.005 1.49 (1.13–1.96) Reference 0.709 (0.021)
 Early signature 33.4 < 0.001 2.06 (1.62–2.61) 0.334 0.678 (0.024) 10.3 0.001 1.55 (1.19–2.02) 0.48 0.711 (0.020)
 Late signature 18.1 < 0.001 1.72 (1.34–2.20) 0.000 0.642 0(.029) 4.3 0.037 1.33 (1.02–1.74) 0.004 0.700 (0.022)
0–5 years  
 CTS 314 (26) 29 < 0.001 2.04 (1.53–2.74) 0.679 (0.023)
 10-Year signature 14.1 < 0.001 2.05 (1.41–2.98) 0.833 0.678 (0.037) 3.2 0.073 1.46 (0.97–2.19) 0.77 0.712 (0.029)
 Early signature 14.9 < 0.001 2.00 (1.42–2.81) Reference 0.672 (0.035) 2.8 0.096 1.40 (0.95–2.06) Reference 0.705 (0.028)
 Late signature 8.9 0.003 1.77 (1.22–2.57) 0.138 0.648 (0.042) 1.7 0.19 1.31 (0.87–1.97) 0.65 0.705 (0.031)
5–10 years  
 CTS 270 (33) 19.8 < 0.001 1.84 (1.33–2.54) 0.657 (0.026)
 10-Year signature 13.9 < 0.001 1.93 (1.37–2.72) 0.027 0.663 (0.036) 4.8 0.028 1.53 (1.05–2.22) 0.14 0.696 (0.030)
 Early signature 18.6 < 0.001 2.11 (1.52–2.94) 0.091 0.681 (0.032) 8 0.005 1.70 (1.19–2.43) 0.14 0.708 (0.028)
 Late signature 9.3 0.002 1.68 (1.21–2.34) Reference 0.636 (0.038) 2.7 0.099 1.36 (0.95–1.94) Reference 0.686 (0.031)
  1. CTS Clinical Treatment Score, LR Likelihood ratio
  2. Both univariate and multivariable analyses are presented for years 0–10, years 0–5, and years 5–10 separately. Likelihood ratio test based on Cox proportional hazards models for univariate and multivariable analyses. Differences in likelihood ratio values (ΔLRχ2) were used. CTS was used as a covariate in the multivariable regressions. For each score, HRs per SD change are presented